(data stored in ACNUC27125 zone)

SWISSPROT: A5D7T5_BOVIN

ID   A5D7T5_BOVIN            Unreviewed;       512 AA.
AC   A5D7T5; F1N2A0;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   11-DEC-2019, entry version 104.
DE   RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE            EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN   Name=PPP3CC {ECO:0000313|EMBL:AAI40676.1,
GN   ECO:0000313|Ensembl:ENSBTAP00000026818, ECO:0000313|VGNC:VGNC:33267};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI40676.1};
RN   [1] {ECO:0000313|EMBL:AAI40676.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Hereford {ECO:0000313|EMBL:AAI40676.1};
RC   TISSUE=Fetal spinal column {ECO:0000313|EMBL:AAI40676.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000026818}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026818};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSBTAP00000026818, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026818,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC         Evidence={ECO:0000256|RuleBase:RU004273};
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC       {ECO:0000256|RuleBase:RU004273}.
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DR   EMBL; BC140675; AAI40676.1; -; mRNA.
DR   RefSeq; NP_001091545.1; NM_001098076.2.
DR   STRING; 9913.ENSBTAP00000026818; -.
DR   Ensembl; ENSBTAT00000026818; ENSBTAP00000026818; ENSBTAG00000020133.
DR   GeneID; 533527; -.
DR   KEGG; bta:533527; -.
DR   CTD; 5533; -.
DR   VGNC; VGNC:33267; PPP3CC.
DR   eggNOG; KOG0375; Eukaryota.
DR   eggNOG; COG0639; LUCA.
DR   GeneTree; ENSGT00940000154115; -.
DR   HOGENOM; HOG000172699; -.
DR   KO; K04348; -.
DR   OMA; ACMNTFD; -.
DR   OrthoDB; 463522at2759; -.
DR   TreeFam; TF105557; -.
DR   Reactome; R-BTA-111447; Activation of BAD and translocation to mitochondria.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000020133; Expressed in 10 organ(s), highest expression level in skeletal muscle tissue.
DR   GO; GO:0005955; C:calcineurin complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0099523; C:presynaptic cytosol; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR   GO; GO:0033192; F:calmodulin-dependent protein phosphatase activity; IBA:GO_Central.
DR   GO; GO:0097720; P:calcineurin-mediated signaling; IBA:GO_Central.
DR   GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR   CDD; cd07416; MPP_PP2B; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041751; MPP_PP2B.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; A5D7T5.
DR   SWISS-2DPAGE; A5D7T5.
KW   Hydrolase {ECO:0000256|RuleBase:RU004273};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          143..148
FT                   /note="SER_THR_PHOSPHATASE"
FT                   /evidence="ECO:0000259|PROSITE:PS00125"
FT   REGION          462..512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  58180 MW;  56F93E8313D532A0 CRC64;
     MSGRNLHLST TERVIKAVPF PPTQRLSLKE VFENGKPKID VLKNHLVKEG RLEEEVALKI
     INDGAAILRQ EKTMIEVDAP VTVCGDIHGQ FFDLMKLFEV GGSPSNTRYL FLGDYVDRGY
     FSIECVLYLW SLKINHPKTL FLLRGNHECR HLTEYFTFKQ ECRIKYSEQV YDACMETFDC
     LPLAALLNQQ FLCVHGGMSP EITCLDDIRK LDRFKEPPAF GPVCDLLWSD PSEDYGNEKT
     LEHYTHNTVR GCSYFYSYPA VCEFLQNNNL LSIIRAHEAQ DAGYRMYRKS QMTGFPSLIT
     IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL PFVGEKVTEM
     LVNILNICSD DELISDDELE GGTTVRKEII KNKIRAIGKM ARVFSILREE SESVLTLKGL
     TPTGTLPLGV LSGGKQTIET AIRGFSLQHR IRSFEEARGL DRINERMPPR KDSQYFDGPV
     KLVQANAAHR SDKGRRASND SEPCGGTGGS KT
//

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