SWISSPROT: A5GQH1_SYNR3

ID   A5GQH1_SYNR3            Unreviewed;       303 AA.
AC   A5GQH1;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   08-MAY-2019, entry version 59.
DE   RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
DE            EC=1.5.1.20 {ECO:0000256|RuleBase:RU003862};
GN   Name=metF {ECO:0000313|EMBL:CAK27130.1};
GN   OrderedLocusNames=SynRCC307_0227 {ECO:0000313|EMBL:CAK27130.1};
OS   Synechococcus sp. (strain RCC307).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae;
OC   Synechococcus.
OX   NCBI_TaxID=316278 {ECO:0000313|EMBL:CAK27130.1, ECO:0000313|Proteomes:UP000001115};
RN   [1] {ECO:0000313|EMBL:CAK27130.1, ECO:0000313|Proteomes:UP000001115}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC307 {ECO:0000313|Proteomes:UP000001115};
RA   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-
CC         5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH;
CC         Xref=Rhea:RHEA:19821, ChEBI:CHEBI:15378, ChEBI:CHEBI:15636,
CC         ChEBI:CHEBI:18608, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=1.5.1.20; Evidence={ECO:0000256|RuleBase:RU003862};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU003862};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|RuleBase:RU003862}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase
CC       family. {ECO:0000256|RuleBase:RU003862}.
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DR   EMBL; CT978603; CAK27130.1; -; Genomic_DNA.
DR   RefSeq; WP_011934645.1; NC_009482.1.
DR   STRING; 316278.SynRCC307_0227; -.
DR   EnsemblBacteria; CAK27130; CAK27130; SynRCC307_0227.
DR   KEGG; syr:SynRCC307_0227; -.
DR   eggNOG; ENOG4107R32; Bacteria.
DR   eggNOG; COG0685; LUCA.
DR   HOGENOM; HOG000016467; -.
DR   KO; K00297; -.
DR   OMA; GIEPICQ; -.
DR   OrthoDB; 1425269at2; -.
DR   BioCyc; SSP316278:G1GJL-223-MONOMER; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000001115; Chromosome.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR003171; Mehydrof_redctse.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; SSF51730; 1.
PE   3: Inferred from homology;
DR   PRODOM; A5GQH1.
DR   SWISS-2DPAGE; A5GQH1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001115};
KW   FAD {ECO:0000256|RuleBase:RU003862};
KW   Flavoprotein {ECO:0000256|RuleBase:RU003862};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003862,
KW   ECO:0000313|EMBL:CAK27130.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001115}.
SQ   SEQUENCE   303 AA;  31742 MW;  5E386E9C9363E6A9 CRC64;
     MSNLLASSLE KALASGQPVI TAEITPPVGA DPSHALEMAE GLRGQVQAFN VTDGSRAVMG
     MSSLALCRLL LERGLEPILQ LGCRDRNRIA LQADLLGAHA LGIRNVLCLT GDPVKAGNQP
     EARAVFDLES VRLLRQVQQL NGGVGPAGKP LADGAPALFP GAAADPQSAS WSGLKSRMRR
     KAEAGARFVQ TQMVMDASAL RRFCTEIAAP LNVPVLAGVF LLKSAKNAAF INRVVPGAQI
     PLPLIDRLAA AENPRLEGIR IAAEQVQSYS AIAAGVHLMA VKAEESLPQV LELAGLPKVV
     AQV
//