(data stored in ACNUC8465 zone)

SWISSPROT: A5PJP8_BOVIN

ID   A5PJP8_BOVIN            Unreviewed;       412 AA.
AC   A5PJP8;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   11-DEC-2019, entry version 100.
DE   SubName: Full=MAP2K4 protein {ECO:0000313|EMBL:AAI42196.1};
DE   SubName: Full=Mitogen-activated protein kinase kinase 4 {ECO:0000313|Ensembl:ENSBTAP00000041598};
GN   Name=MAP2K4 {ECO:0000313|EMBL:AAI42196.1,
GN   ECO:0000313|Ensembl:ENSBTAP00000041598, ECO:0000313|VGNC:VGNC:31185};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI42196.1};
RN   [1] {ECO:0000313|EMBL:AAI42196.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Hereford {ECO:0000313|EMBL:AAI42196.1};
RC   TISSUE=Heart ventrical {ECO:0000313|EMBL:AAI42196.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000041598}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000041598};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSBTAP00000041598, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000041598,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC       {ECO:0000256|RuleBase:RU000304}.
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DR   EMBL; BC142195; AAI42196.1; -; mRNA.
DR   RefSeq; NP_001092508.1; NM_001099038.1.
DR   STRING; 9913.ENSBTAP00000041598; -.
DR   Ensembl; ENSBTAT00000044085; ENSBTAP00000041598; ENSBTAG00000012103.
DR   GeneID; 526469; -.
DR   KEGG; bta:526469; -.
DR   CTD; 6416; -.
DR   VGNC; VGNC:31185; MAP2K4.
DR   eggNOG; KOG0984; Eukaryota.
DR   eggNOG; ENOG410XT3F; LUCA.
DR   GeneTree; ENSGT00940000154744; -.
DR   HOGENOM; HOG000234206; -.
DR   KO; K04430; -.
DR   OMA; MKSNDCN; -.
DR   OrthoDB; 688282at2759; -.
DR   TreeFam; TF350701; -.
DR   Reactome; R-BTA-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-BTA-2871796; FCERI mediated MAPK activation.
DR   Reactome; R-BTA-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000012103; Expressed in 10 organ(s), highest expression level in brain.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008545; F:JUN kinase kinase activity; IBA:GO_Central.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IBA:GO_Central.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0007257; P:activation of JUN kinase activity; IBA:GO_Central.
DR   GO; GO:0000187; P:activation of MAPK activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:2000672; P:negative regulation of motor neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0009611; P:response to wounding; IEA:Ensembl.
DR   GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; A5PJP8.
DR   SWISS-2DPAGE; A5PJP8.
KW   ATP-binding {ECO:0000256|RuleBase:RU000304};
KW   Kinase {ECO:0000256|RuleBase:RU000304};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
KW   Transferase {ECO:0000256|RuleBase:RU000304}.
FT   DOMAIN          115..380
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   412 AA;  45610 MW;  E4DCA91D38E5601A CRC64;
     MAAPSPSGGG GGGGGSGGGS GTPGPAGSPA PGHPAVSSMQ GFQINFCEKA QSKRKALKLN
     FANPPFKSTA RFTLNPNPAG VQNPHIERLR THSIESSGKL KISPEQHWDF TAEDLKDLGE
     IGRGAYGSVN KMVHKPSGQI MAVKRIRSTV DEKEQKQLLM DLDVVMRSSD CPYIVQFYGA
     LFREGDCWIC MELMSTSFDK FYKYVYSVLD DVIPEEILGK ITLATVKALN HLKENLKIIH
     RDIKPSNILL DRSGNIKLCD FGISGQLVDS IAKTRDAGCR PYMAPERIDP SASRQGYDVR
     SDVWSLGITL YELATGRFPY PKWNSVFDQL TQVVKGDPPQ LSNSEEREFS PSFINFVNLC
     LTKDESKRPK YKELLKHPFI LMYEERAVEV ACYVCKILDQ MPATPSSPMY VD
//

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