(data stored in ACNUC7820 zone)

SWISSPROT: O14I1_HUMAN

ID   O14I1_HUMAN             Reviewed;         311 AA.
AC   A6ND48;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   30-AUG-2017, entry version 83.
DE   RecName: Full=Olfactory receptor 14I1;
DE   AltName: Full=Olfactory receptor 5BU1;
GN   Name=OR14I1; Synonyms=OR5BU1, OR5BU1P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
CC       (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR14I1";
DR   EMBL; AC098483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS31125.1; -.
DR   RefSeq; NP_001004734.1; NM_001004734.1.
DR   RefSeq; XP_005273189.1; XM_005273132.3.
DR   UniGene; Hs.449973; -.
DR   ProteinModelPortal; A6ND48; -.
DR   BioGrid; 135302; 1.
DR   IntAct; A6ND48; 1.
DR   STRING; 9606.ENSP00000339726; -.
DR   iPTMnet; A6ND48; -.
DR   PhosphoSitePlus; A6ND48; -.
DR   BioMuta; OR14I1; -.
DR   PaxDb; A6ND48; -.
DR   PRIDE; A6ND48; -.
DR   Ensembl; ENST00000342623; ENSP00000339726; ENSG00000189181.
DR   GeneID; 401994; -.
DR   KEGG; hsa:401994; -.
DR   UCSC; uc001ieu.1; human.
DR   CTD; 401994; -.
DR   GeneCards; OR14I1; -.
DR   HGNC; HGNC:19575; OR14I1.
DR   neXtProt; NX_A6ND48; -.
DR   OpenTargets; ENSG00000189181; -.
DR   PharmGKB; PA162398443; -.
DR   eggNOG; ENOG410IE8E; Eukaryota.
DR   eggNOG; ENOG4111AED; LUCA.
DR   GeneTree; ENSGT00760000118849; -.
DR   HOGENOM; HOG000041364; -.
DR   HOVERGEN; HBG017625; -.
DR   InParanoid; A6ND48; -.
DR   KO; K04257; -.
DR   OMA; WLSCFSY; -.
DR   OrthoDB; EOG091G0CU6; -.
DR   PhylomeDB; A6ND48; -.
DR   TreeFam; TF352740; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   GenomeRNAi; 401994; -.
DR   PRO; PR:A6ND48; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000189181; -.
DR   CleanEx; HS_OR14I1; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A6ND48.
DR   SWISS-2DPAGE; A6ND48.
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
KW   Polymorphism; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    311       Olfactory receptor 14I1.
FT                                /FTId=PRO_0000310414.
FT   TOPO_DOM      1     26       Extracellular. {ECO:0000255}.
FT   TRANSMEM     27     47       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     48     55       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     56     76       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     77     92       Extracellular. {ECO:0000255}.
FT   TRANSMEM     93    113       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    114    141       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    142    162       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    163    189       Extracellular. {ECO:0000255}.
FT   TRANSMEM    190    210       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    211    241       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    242    262       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    263    269       Extracellular. {ECO:0000255}.
FT   TRANSMEM    270    290       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    291    311       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD      3      3       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     95    188       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   VARIANT      36     36       V -> A (in dbSNP:rs4462184).
FT                                /FTId=VAR_037030.
FT   VARIANT      50     50       D -> N (in dbSNP:rs4509608).
FT                                /FTId=VAR_037031.
FT   VARIANT      84     84       L -> M (in dbSNP:rs41311583).
FT                                /FTId=VAR_062073.
FT   VARIANT     170    170       S -> N (in dbSNP:rs2000390).
FT                                /FTId=VAR_037032.
FT   VARIANT     216    216       Y -> C (in dbSNP:rs55871516).
FT                                /FTId=VAR_062074.
SQ   SEQUENCE   311 AA;  35175 MW;  2AC007546D7A9C59 CRC64;
     MDNLTKVTEF LLMEFSGIWE LQVLHAGLFL LIYLAVLVGN LLIIAVITLD QHLHTPMYFF
     LKNLSVLDLC YISVTVPKSI RNSLTRRSSI SYLGCVAQVY FFSAFASAEL AFLTVMSYDR
     YVAICHPLQY RAVMTSGGCY QMAVTTWLSC FSYAAVHTGN MFREHVCRSS VIHQFFRDIP
     HVLALVSCEV FFVEFLTLAL SSCLVLGCFI LMMISYFQIF STVLRIPSGQ SRAKAFSTCS
     PQLIVIMLFL TTGLFAALGP IAKALSIQDL VIALTYTVLP PFLNPIIYSL RNKEIKTAMW
     RLFVKIYFLQ K
//

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