(data stored in ACNUC8465 zone)

SWISSPROT: A6NK28_HUMAN

ID   A6NK28_HUMAN            Unreviewed;       258 AA.
AC   A6NK28;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   11-DEC-2019, entry version 83.
DE   SubName: Full=Dual-specificity mitogen-activated protein kinase kinase 5 {ECO:0000313|Ensembl:ENSP00000342101};
GN   Name=MAP2K5 {ECO:0000313|Ensembl:ENSP00000342101};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000342101, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000342101, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA   Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA   Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000213|PubMed:19369195}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
RA   Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA   Mann M., Daub H.;
RT   "Large-scale proteomics analysis of the human kinome.";
RL   Mol. Cell. Proteomics 8:1751-1764(2009).
RN   [3] {ECO:0000313|Ensembl:ENSP00000342101}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC009292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC103753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EPD; A6NK28; -.
DR   jPOST; A6NK28; -.
DR   MaxQB; A6NK28; -.
DR   PeptideAtlas; A6NK28; -.
DR   PRIDE; A6NK28; -.
DR   ProteomicsDB; 1373; -.
DR   Ensembl; ENST00000340972; ENSP00000342101; ENSG00000137764.
DR   UCSC; uc002aqx.4; human.
DR   EuPathDB; HostDB:ENSG00000137764.19; -.
DR   HGNC; HGNC:6845; MAP2K5.
DR   OpenTargets; ENSG00000137764; -.
DR   eggNOG; KOG0581; Eukaryota.
DR   eggNOG; ENOG410XQ5A; LUCA.
DR   GeneTree; ENSGT00940000157505; -.
DR   HOGENOM; HOG000234206; -.
DR   SignaLink; A6NK28; -.
DR   ChiTaRS; MAP2K5; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000137764; Expressed in 218 organ(s), highest expression level in frontal cortex.
DR   ExpressionAtlas; A6NK28; baseline and differential.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   1: Evidence at protein level;
DR   PRODOM; A6NK28.
DR   SWISS-2DPAGE; A6NK28.
KW   Proteomics identification {ECO:0000213|EPD:A6NK28,
KW   ECO:0000213|MaxQB:A6NK28, ECO:0000213|PeptideAtlas:A6NK28,
KW   ECO:0000213|ProteomicsDB:A6NK28};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          1..229
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   258 AA;  29233 MW;  DA8ADF712A028F19 CRC64;
     MEDFEVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC TEFMDGGSLD
     VYRKMPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC DFGVSTQLVN
     SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ KNQGSLMPLQ
     LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV QFNDGNAAVV
     SMWVCRALEE RRSQQGPP
//

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