(data stored in ACNUC27125 zone)

SWISSPROT: A7SJ38_NEMVE

ID   A7SJ38_NEMVE            Unreviewed;       461 AA.
AC   A7SJ38;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   11-DEC-2019, entry version 71.
DE   RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE            EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN   ORFNames=v1g245588 {ECO:0000313|EMBL:EDO36272.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO36272.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC         Evidence={ECO:0000256|RuleBase:RU004273};
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC       {ECO:0000256|RuleBase:RU004273}.
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DR   EMBL; DS469674; EDO36272.1; -; Genomic_DNA.
DR   RefSeq; XP_001628335.1; XM_001628285.1.
DR   STRING; 45351.EDO36272; -.
DR   EnsemblMetazoa; EDO36272; EDO36272; NEMVEDRAFT_v1g245588.
DR   GeneID; 5507715; -.
DR   KEGG; nve:NEMVE_v1g245588; -.
DR   eggNOG; KOG0375; Eukaryota.
DR   eggNOG; COG0639; LUCA.
DR   HOGENOM; HOG000172699; -.
DR   InParanoid; A7SJ38; -.
DR   KO; K04348; -.
DR   OMA; NMITIEA; -.
DR   OrthoDB; 463522at2759; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005955; C:calcineurin complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR   GO; GO:0033192; F:calmodulin-dependent protein phosphatase activity; IBA:GO_Central.
DR   GO; GO:0097720; P:calcineurin-mediated signaling; IBA:GO_Central.
DR   CDD; cd07416; MPP_PP2B; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041751; MPP_PP2B.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; A7SJ38.
DR   SWISS-2DPAGE; A7SJ38.
KW   Hydrolase {ECO:0000256|RuleBase:RU004273};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT   DOMAIN          125..130
FT                   /note="SER_THR_PHOSPHATASE"
FT                   /evidence="ECO:0000259|PROSITE:PS00125"
FT   REGION          430..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        433..461
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   461 AA;  52571 MW;  8CA027B153D90892 CRC64;
     MPPVNRLTMA DVYDSNGKPR ADVLKAHFIL EGRVEDEVAL KIINDGTAIL RKEKTMLEVD
     APITVCGDIH GQFYDLVKLF EVGGSPATTR YLFLGDYVDR GYFSIECVLY LWTLKCLYTN
     TLFLLRGNHE CRHLTEYFTF KTECKIKYSE AVYDACMESF DCLPLAALMN QQFLCVHGGL
     SPEIHTLDDV KKLDRFKEPP AFGPMCDLLW SDPLEDYGNE KTSEHFSHNT VRGCSYFYSY
     PATCEFLQNN NLLSIIRAHE AQDAGYRMYR KSQATGFPSL ITIFSAPNYL DVYNNKAAVL
     KYENNVMNIR QFNCSPHPYW LPNFMDVFTW SLPFVGEKVT EMLVNILSIC TDEELEDGDE
     DEEKTEALKR KEIIRSKIRA IGKMARVFTV LREESESILQ LKGLTPTGHL PVGLLSGGKQ
     EVQAALQGHD PTHKISGFEE AKGLDRVNER MPPRKDMPRP K
//

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