(data stored in ACNUC16935 zone)


ID   A7U5U2_PIG              Unreviewed;       229 AA.
AC   A7U5U2;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   30-AUG-2017, entry version 79.
DE   SubName: Full=Ubiquitin B {ECO:0000313|EMBL:ABU49130.1};
GN   Name=UBB {ECO:0000313|EMBL:ABU49130.1,
GN   ECO:0000313|Ensembl:ENSSSCP00000019108};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1] {ECO:0000313|EMBL:ABU49130.1}
RA   Xie S., Li J.;
RT   "Sus scrofa ubiquitin B gene.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000019108, ECO:0000313|Proteomes:UP000008227}
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSSSCP00000019108}
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; CU927969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EF688558; ABU49130.1; -; mRNA.
DR   EMBL; EF688559; ABU49131.1; -; Genomic_DNA.
DR   RefSeq; NP_001098779.1; NM_001105309.1.
DR   RefSeq; XP_005654051.1; XM_005653994.2.
DR   UniGene; Ssc.18568; -.
DR   STRING; 9823.ENSSSCP00000019108; -.
DR   Ensembl; ENSSSCT00000019628; ENSSSCP00000019108; ENSSSCG00000018033.
DR   GeneID; 100125968; -.
DR   KEGG; ssc:100125968; -.
DR   CTD; 7314; -.
DR   eggNOG; KOG0001; Eukaryota.
DR   eggNOG; COG5272; LUCA.
DR   GeneTree; ENSGT00810000125435; -.
DR   HOGENOM; HOG000233942; -.
DR   HOVERGEN; HBG000057; -.
DR   KO; K04551; -.
DR   OrthoDB; EOG091G178I; -.
DR   TreeFam; TF300820; -.
DR   Reactome; R-SSC-110312; Translesion synthesis by REV1.
DR   Reactome; R-SSC-110314; Recognition of DNA damage by PCNA-containing replication complex.
DR   Reactome; R-SSC-110320; Translesion Synthesis by POLH.
DR   Reactome; R-SSC-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR   Reactome; R-SSC-1253288; Downregulation of ERBB4 signaling.
DR   Reactome; R-SSC-1295596; Spry regulation of FGF signaling.
DR   Reactome; R-SSC-1358803; Downregulation of ERBB2:ERBB3 signaling.
DR   Reactome; R-SSC-168638; NOD1/2 Signaling Pathway.
DR   Reactome; R-SSC-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR   Reactome; R-SSC-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR   Reactome; R-SSC-174154; APC/C:Cdc20 mediated degradation of Securin.
DR   Reactome; R-SSC-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR   Reactome; R-SSC-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR   Reactome; R-SSC-179409; APC-Cdc20 mediated degradation of Nek2A.
DR   Reactome; R-SSC-182971; EGFR downregulation.
DR   Reactome; R-SSC-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR   Reactome; R-SSC-195253; Degradation of beta-catenin by the destruction complex.
DR   Reactome; R-SSC-201681; TCF dependent signaling in response to WNT.
DR   Reactome; R-SSC-209543; p75NTR recruits signalling complexes.
DR   Reactome; R-SSC-209560; NF-kB is activated and signals survival.
DR   Reactome; R-SSC-2173788; Downregulation of TGF-beta receptor signaling.
DR   Reactome; R-SSC-2173791; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
DR   Reactome; R-SSC-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
DR   Reactome; R-SSC-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
DR   Reactome; R-SSC-2467813; Separation of Sister Chromatids.
DR   Reactome; R-SSC-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-SSC-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR   Reactome; R-SSC-2559585; Oncogene Induced Senescence.
DR   Reactome; R-SSC-2672351; Stimuli-sensing channels.
DR   Reactome; R-SSC-3134975; Regulation of innate immune responses to cytosolic DNA.
DR   Reactome; R-SSC-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR   Reactome; R-SSC-3769402; Deactivation of the beta-catenin transactivating complex.
DR   Reactome; R-SSC-382556; ABC-family proteins mediated transport.
DR   Reactome; R-SSC-445989; TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
DR   Reactome; R-SSC-446652; Interleukin-1 signaling.
DR   Reactome; R-SSC-450302; activated TAK1 mediates p38 MAPK activation.
DR   Reactome; R-SSC-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
DR   Reactome; R-SSC-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR   Reactome; R-SSC-4641257; Degradation of AXIN.
DR   Reactome; R-SSC-4641258; Degradation of DVL.
DR   Reactome; R-SSC-4641263; Regulation of FZD by ubiquitination.
DR   Reactome; R-SSC-532668; N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
DR   Reactome; R-SSC-5357905; Regulation of TNFR1 signaling.
DR   Reactome; R-SSC-5357956; TNFR1-induced NFkappaB signaling pathway.
DR   Reactome; R-SSC-5358346; Hedgehog ligand biogenesis.
DR   Reactome; R-SSC-5607761; Dectin-1 mediated noncanonical NF-kB signaling.
DR   Reactome; R-SSC-5632684; Hedgehog 'on' state.
DR   Reactome; R-SSC-5654726; Negative regulation of FGFR1 signaling.
DR   Reactome; R-SSC-5654727; Negative regulation of FGFR2 signaling.
DR   Reactome; R-SSC-5654732; Negative regulation of FGFR3 signaling.
DR   Reactome; R-SSC-5654733; Negative regulation of FGFR4 signaling.
DR   Reactome; R-SSC-5655862; Translesion synthesis by POLK.
DR   Reactome; R-SSC-5656121; Translesion synthesis by POLI.
DR   Reactome; R-SSC-5656169; Termination of translesion DNA synthesis.
DR   Reactome; R-SSC-5668541; TNFR2 non-canonical NF-kB pathway.
DR   Reactome; R-SSC-5675221; Negative regulation of MAPK pathway.
DR   Reactome; R-SSC-5675482; Regulation of necroptotic cell death.
DR   Reactome; R-SSC-5676590; NIK-->noncanonical NF-kB signaling.
DR   Reactome; R-SSC-5685942; HDR through Homologous Recombination (HRR).
DR   Reactome; R-SSC-5687128; MAPK6/MAPK4 signaling.
DR   Reactome; R-SSC-5689603; UCH proteinases.
DR   Reactome; R-SSC-5689877; Josephin domain DUBs.
DR   Reactome; R-SSC-5689880; Ub-specific processing proteases.
DR   Reactome; R-SSC-5689896; Ovarian tumor domain proteases.
DR   Reactome; R-SSC-5689901; Metalloprotease DUBs.
DR   Reactome; R-SSC-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
DR   Reactome; R-SSC-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-SSC-5696395; Formation of Incision Complex in GG-NER.
DR   Reactome; R-SSC-5696397; Gap-filling DNA repair synthesis and ligation in GG-NER.
DR   Reactome; R-SSC-5696400; Dual Incision in GG-NER.
DR   Reactome; R-SSC-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-SSC-6782135; Dual incision in TC-NER.
DR   Reactome; R-SSC-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-SSC-6783310; Fanconi Anemia Pathway.
DR   Reactome; R-SSC-6804756; Regulation of TP53 Activity through Phosphorylation.
DR   Reactome; R-SSC-6804757; Regulation of TP53 Degradation.
DR   Reactome; R-SSC-6804760; Regulation of TP53 Activity through Methylation.
DR   Reactome; R-SSC-6807004; Negative regulation of MET activity.
DR   Reactome; R-SSC-68827; CDT1 association with the CDC6:ORC:origin complex.
DR   Reactome; R-SSC-68949; Orc1 removal from chromatin.
DR   Reactome; R-SSC-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   Reactome; R-SSC-69229; Ubiquitin-dependent degradation of Cyclin D1.
DR   Reactome; R-SSC-69231; Cyclin D associated events in G1.
DR   Reactome; R-SSC-69298; Association of licensing factors with the pre-replicative complex.
DR   Reactome; R-SSC-69481; G2/M Checkpoints.
DR   Reactome; R-SSC-69541; Stabilization of p53.
DR   Reactome; R-SSC-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR   Reactome; R-SSC-8849469; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
DR   Reactome; R-SSC-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint.
DR   Reactome; R-SSC-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR   Reactome; R-SSC-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-SSC-8856828; Clathrin-mediated endocytosis.
DR   Reactome; R-SSC-8863795; Downregulation of ERBB2 signaling.
DR   Reactome; R-SSC-8866652; Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
DR   Reactome; R-SSC-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR   Reactome; R-SSC-8941858; Regulation of RUNX3 expression and activity.
DR   Reactome; R-SSC-8951664; Neddylation.
DR   Reactome; R-SSC-912631; Regulation of signaling by CBL.
DR   Reactome; R-SSC-917937; Iron uptake and transport.
DR   Reactome; R-SSC-936440; Negative regulators of RIG-I/MDA5 signaling.
DR   Reactome; R-SSC-937042; IRAK2 mediated activation of TAK1 complex.
DR   Reactome; R-SSC-937072; TRAF6 mediated induction of TAK1 complex.
DR   Reactome; R-SSC-975163; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
DR   Reactome; R-SSC-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   Proteomes; UP000008227; Chromosome 12.
DR   Bgee; ENSSSCG00000018033; -.
DR   InterPro; IPR019956; Ubiquitin.
DR   InterPro; IPR029071; Ubiquitin-rel_dom.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR000626; Ubiquitin_dom.
DR   Pfam; PF00240; ubiquitin; 3.
DR   SMART; SM00213; UBQ; 3.
DR   SUPFAM; SSF54236; SSF54236; 3.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN        1     76       Ubiquitin-like. {ECO:0000259|PROSITE:
FT                                PS50053}.
FT   DOMAIN       77    152       Ubiquitin-like. {ECO:0000259|PROSITE:
FT                                PS50053}.
FT   DOMAIN      153    228       Ubiquitin-like. {ECO:0000259|PROSITE:
FT                                PS50053}.
SQ   SEQUENCE   229 AA;  25762 MW;  33011162F1C48BB1 CRC64;

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