(data stored in SCRATCH zone)

SWISSPROT: A8FPD6_SHESH

ID   A8FPD6_SHESH            Unreviewed;       933 AA.
AC   A8FPD6;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   30-AUG-2017, entry version 81.
DE   RecName: Full=DNA polymerase I {ECO:0000256|RuleBase:RU004460};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU004460};
GN   Name=polA {ECO:0000256|RuleBase:RU004460};
GN   OrderedLocusNames=Ssed_0096 {ECO:0000313|EMBL:ABV34709.1};
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104 {ECO:0000313|EMBL:ABV34709.1, ECO:0000313|Proteomes:UP000002015};
RN   [1] {ECO:0000313|EMBL:ABV34709.1, ECO:0000313|Proteomes:UP000002015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3 {ECO:0000313|EMBL:ABV34709.1,
RC   ECO:0000313|Proteomes:UP000002015};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In addition to polymerase activity, this DNA polymerase
CC       exhibits 5'-3' exonuclease activity.
CC       {ECO:0000256|RuleBase:RU004460}.
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1). {ECO:0000256|RuleBase:RU004460}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|RuleBase:RU004460}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000821; ABV34709.1; -; Genomic_DNA.
DR   ProteinModelPortal; A8FPD6; -.
DR   SMR; A8FPD6; -.
DR   STRING; 425104.Ssed_0096; -.
DR   EnsemblBacteria; ABV34709; ABV34709; Ssed_0096.
DR   KEGG; sse:Ssed_0096; -.
DR   eggNOG; ENOG4105C2M; Bacteria.
DR   eggNOG; COG0258; LUCA.
DR   eggNOG; COG0749; LUCA.
DR   HOGENOM; HOG000020999; -.
DR   KO; K02335; -.
DR   OMA; ETGRVHT; -.
DR   OrthoDB; POG091H00PR; -.
DR   BioCyc; SSED425104:GH7Q-99-MONOMER; -.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.40.50.1010; -; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR020045; 5-3_exonuclease_C.
DR   InterPro; IPR002421; 5-3_exonuclease_N.
DR   InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR018320; DNA_polymerase_1.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN_domain-like.
DR   InterPro; IPR012337; RNaseH-like_dom.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
DR   TIGRFAMs; TIGR00593; pola; 1.
DR   PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8FPD6.
DR   SWISS-2DPAGE; A8FPD6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002015};
KW   DNA damage {ECO:0000256|RuleBase:RU004460};
KW   DNA repair {ECO:0000256|RuleBase:RU004460};
KW   DNA replication {ECO:0000256|RuleBase:RU004460};
KW   DNA-binding {ECO:0000256|RuleBase:RU004460};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU004460,
KW   ECO:0000313|EMBL:ABV34709.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00636373};
KW   Nuclease {ECO:0000256|SAAS:SAAS00636380};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU004460,
KW   ECO:0000313|EMBL:ABV34709.1};
KW   Transferase {ECO:0000256|RuleBase:RU004460,
KW   ECO:0000313|EMBL:ABV34709.1}.
FT   DOMAIN       21    282       53EXOc. {ECO:0000259|SMART:SM00475}.
FT   DOMAIN      334    521       3'-5' exonuclease. {ECO:0000259|SMART:
FT                                SM00474}.
FT   DOMAIN      690    897       POLAc. {ECO:0000259|SMART:SM00482}.
SQ   SEQUENCE   933 AA;  103431 MW;  5B975F40A50683BD CRC64;
     MLAASSKIKN RILIMPKIAE NPLVLVDGSS YLYRAYYAPP HLTNSKGEAT GAVYGVINML
     RSLLNQYKPS QMAVVFDAKG KTFRNDMYEE YKAHRPAMPD DLRSQIEPLH RIIRALGLPL
     VCIPGVEADD VIGTISTQAS KEGRAVLIST GDKDMAQLVD ENVTLINTMT NTIMGPSEVT
     EKFGVGPELI IDLLALQGDK ADNIPGLPGV GEKTALAMLT GAGSIDKILA APEKMPELGF
     RGSKTMPAKL AEHGDMLKLS YELATIKLDV ELEQDWKDLT IAPADKDELI KCYGEMEFKR
     WLAEVLDNRS GSSASTQTST EEDELPKQDI KTEYSTILTH DELDEWIDKL SKAELFAVDT
     ETTSLNYMEA KLVGLSFAVE AGKAAYLPLA HDYLDAPQQL NQAEALAKLK PLLENPEIKK
     VGQNLKYDMS ILANVGIKLQ GIAFDTMLES YVFNSVASKH NMDDLALKYL GHKNISFEEI
     AGKGAKQLTF NQISLEVAAP YAAEDADITL RLHQHLWPRL QKEPELASIF TEIELPLVQV
     LSDMERQGVL IDSMLLGQQS EELARTIDEL EQKAYEIAGE SFNLSSPKQL QVLFFEKLGY
     PIIKKTPKGA PSTAEEVLVE LALDYPLPKI ILQHRSLAKL KSTYTDKLPL MVNAQTGRVH
     TSYHQANAAT GRLSSSEPNL QNIPIRTEEG RRIRHAFIAR EGRKVLAADY SQIELRIMAH
     LSQDKGLLTA FAEGKDIHKA TAAEVFDVDF TEVTTEQRRR AKAVNFGLIY GMSAFGLARQ
     LDIPRGEAQK YIDTYFKRYP GVLNYMEETR AIAADLGYVS TLYGRRLYLP AIKDRNAMRR
     QAAERAAINA PMQGTAADII KKAMINVADW IANETDGEIT LIMQVHDELV FEVDSDKAEA
     LQEKVCQLMA EAADLDVELL AEAGLGDNWE QAH
//

If you have problems or comments...

PBIL Back to PBIL home page