(data stored in SCRATCH zone)

SWISSPROT: A8FPE7_SHESH

ID   A8FPE7_SHESH            Unreviewed;       367 AA.
AC   A8FPE7;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   07-JUN-2017, entry version 66.
DE   RecName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000256|RuleBase:RU004473};
DE            EC=4.2.1.46 {ECO:0000256|RuleBase:RU004473};
GN   OrderedLocusNames=Ssed_0107 {ECO:0000313|EMBL:ABV34720.1};
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104 {ECO:0000313|EMBL:ABV34720.1, ECO:0000313|Proteomes:UP000002015};
RN   [1] {ECO:0000313|EMBL:ABV34720.1, ECO:0000313|Proteomes:UP000002015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3 {ECO:0000313|EMBL:ABV34720.1,
RC   ECO:0000313|Proteomes:UP000002015};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-
CC       alpha-D-glucose + H(2)O. {ECO:0000256|RuleBase:RU004473}.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|RuleBase:RU004473};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. dTDP-glucose dehydratase subfamily.
CC       {ECO:0000256|RuleBase:RU004473}.
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DR   EMBL; CP000821; ABV34720.1; -; Genomic_DNA.
DR   ProteinModelPortal; A8FPE7; -.
DR   STRING; 425104.Ssed_0107; -.
DR   EnsemblBacteria; ABV34720; ABV34720; Ssed_0107.
DR   KEGG; sse:Ssed_0107; -.
DR   eggNOG; ENOG4105C1B; Bacteria.
DR   eggNOG; COG1088; LUCA.
DR   HOGENOM; HOG000168006; -.
DR   KO; K01710; -.
DR   OMA; MIPTIIR; -.
DR   OrthoDB; POG091H044P; -.
DR   BioCyc; SSED425104:GH7Q-110-MONOMER; -.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR   InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01181; dTDP_gluc_dehyt; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8FPE7.
DR   SWISS-2DPAGE; A8FPE7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002015};
KW   Lyase {ECO:0000256|RuleBase:RU004473}.
FT   DOMAIN       10    330       NAD(P)-bd_dom. {ECO:0000259|Pfam:
FT                                PF16363}.
SQ   SEQUENCE   367 AA;  41477 MW;  9ABAC508A5A67CE5 CRC64;
     MSMHKDKTVL VTGGAGFIGS ALVRFLINET SHRVINLDKL TYAGNLESLT SIESNERYHF
     ILGDICDRPL VDDILKRYQP DIIMHLAAES HVDRSIDGPD EFIQTNILGT YTLLEASRSY
     LAELEGCKQQ DFRFHHISTD EVYGDLGETG LFTEQSPYNP SSPYSASKAA SDHLVRAWCR
     TFQLPVVITN CSNNYGPFQF PEKLIPLVIL NALEGKPLPV YGDGKQVRDW LYVDDHARAL
     YKVATDGKPG STYNIGGYNE KQNIDVITTI CDQLNSLIES KPSGIEEFNQ LITYVKDRPG
     HDLRYAIDAT KIKNELGWKP VETFESGIVK TIQWYLDNLE WCRHIRDGSY RKISANDNNQ
     MDETPNG
//

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