(data stored in ACNUC1104 zone)

SWISSPROT: A8KYD1_FRASN

ID   A8KYD1_FRASN            Unreviewed;       502 AA.
AC   A8KYD1;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   08-MAY-2019, entry version 66.
DE   SubName: Full=Drug resistance transporter, EmrB/QacA subfamily {ECO:0000313|EMBL:ABW15921.1};
GN   OrderedLocusNames=Franean1_6584 {ECO:0000313|EMBL:ABW15921.1};
OS   Frankia sp. (strain EAN1pec).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW15921.1, ECO:0000313|Proteomes:UP000001313};
RN   [1] {ECO:0000313|Proteomes:UP000001313}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EAN1pec {ECO:0000313|Proteomes:UP000001313};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; CP000820; ABW15921.1; -; Genomic_DNA.
DR   RefSeq; WP_020463992.1; NC_009921.1.
DR   EnsemblBacteria; ABW15921; ABW15921; Franean1_6584.
DR   KEGG; fre:Franean1_6584; -.
DR   eggNOG; ENOG4105C57; Bacteria.
DR   eggNOG; COG0477; LUCA.
DR   HOGENOM; HOG000239124; -.
DR   OMA; GNKKGWL; -.
DR   OrthoDB; 1108236at2; -.
DR   BioCyc; FSP298653:G1G9X-6750-MONOMER; -.
DR   Proteomes; UP000001313; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8KYD1.
DR   SWISS-2DPAGE; A8KYD1.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001313};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001313};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     12     34       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     54     70       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     82    104       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    140    161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    167    188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    200    218       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    230    247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    268    291       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    297    319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    356    377       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    407    425       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    431    455       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       12    459       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   502 AA;  51586 MW;  3B8B489FFAA4217E CRC64;
     MAEPTSRRRF AVLAICCMSL LIVGLDGTIV NVALPALRRD LGASPAGLQW TIDSYTLVLA
     SLLMLGGSTG DRLGRRRIFQ TGLALFTAGS LLCSLAPGLG WLVVFRMVQA VGGSMLNPVA
     MSIITNTFTD PRERARAIGL WGAVIGISMA LGPVLGGILV ETVSWRAIFW INIPIGLAAL
     VLTHRFVPES RAPSPRRLDP VGQLLVIAVL ATLTYSIIEA PAAGWTSAET LVLLAVAVAA
     AALLVGYESR RTEPLLDVRF FRSAPFSGAT AIAVCAFGAL AGFLFLNTIY LQDVRGYSAL
     HAGLLTLPMA LATLVIAPLS GRAVGRFGPR PSLLAAGVAL TAGSAAMTGL SPQTSVTTLM
     VAYVLFGTGF GLVNAPITNT AVSGMPLEQA GVAAAVASTS RQVGQSLGVA VIGSVAAATA
     TVGAVDPTST AAWWAVVAAC AAVLALGFAT TGTWARRTAD QTRSRLLTTL APGQAATPQE
     GTQQAGNQQA AHPVTAEPEP SP
//

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