(data stored in ACNUC1104 zone)

SWISSPROT: A8L0K7_FRASN

ID   A8L0K7_FRASN            Unreviewed;       488 AA.
AC   A8L0K7;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   SubName: Full=Drug resistance transporter, EmrB/QacA subfamily {ECO:0000313|EMBL:ABW14540.1};
GN   OrderedLocusNames=Franean1_5182 {ECO:0000313|EMBL:ABW14540.1};
OS   Frankia sp. (strain EAN1pec).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW14540.1, ECO:0000313|Proteomes:UP000001313};
RN   [1] {ECO:0000313|Proteomes:UP000001313}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EAN1pec {ECO:0000313|Proteomes:UP000001313};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; CP000820; ABW14540.1; -; Genomic_DNA.
DR   RefSeq; WP_020462654.1; NC_009921.1.
DR   STRING; 298653.Franean1_5182; -.
DR   EnsemblBacteria; ABW14540; ABW14540; Franean1_5182.
DR   KEGG; fre:Franean1_5182; -.
DR   eggNOG; ENOG4105C0R; Bacteria.
DR   eggNOG; ENOG410XNN3; LUCA.
DR   HOGENOM; HOG000239124; -.
DR   OMA; NGAWIST; -.
DR   OrthoDB; 1108236at2; -.
DR   BioCyc; FSP298653:G1G9X-5251-MONOMER; -.
DR   Proteomes; UP000001313; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 2.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8L0K7.
DR   SWISS-2DPAGE; A8L0K7.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001313};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001313};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM      7     29       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     49     69       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     76     95       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    107    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    134    153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    165    183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    195    215       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    227    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    266    291       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    303    321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    333    352       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    364    384       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    405    425       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    437    455       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       11    460       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   488 AA;  49238 MW;  957895B7534624B2 CRC64;
     MTDKRSATVW TFVVTSITAF MVALDNLVVT TALPQIRGDL GAGLEGLEWV VNAYTLPFAV
     LLLTGAALGD RLGRRAVFAT GLGVFTLGSL GAALAPSIEA LIAARAMQGV GAALVLPLSL
     TLLSAAVPPE RRGAALGVWG AMSGLAVAVG PLVGGAITDG ASWQWIFWLN VPIGLVTVPL
     ALRRLTESRG PAGRLDLPGV AIISAGLLGV TLGLVRGESH GWTSPAVLTS LLAGVAGVGA
     FIAWERRVAR RGGSPMLPMA LFRRRGFAAV NAVSLLFSVG MFGSIFLLAQ ALQNVFDYSP
     LEAGIRTLPW TAMPLLIAPI AGPLSDRIGG RPLIVAGMAI EAVSLAWLAT ILDTGADYAG
     LVPPFVLAGV GMALFFVPVA SVALGSVPAE QEGLASGTNN AMRELGGVLG VAVLASVFAA
     NGGYASPGAF VDGTRPALWV GAAVLLTAAA VATLLPSPAR TAAPATPPAP AAPAASQALP
     VVGRPSSA
//

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