(data stored in SCRATCH zone)

SWISSPROT: A8LCH9_FRASN

ID   A8LCH9_FRASN            Unreviewed;       293 AA.
AC   A8LCH9;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   08-MAY-2019, entry version 51.
DE   RecName: Full=1,4-dihydroxy-6-naphtoate synthase {ECO:0000256|HAMAP-Rule:MF_00996};
DE            EC=4.1.-.- {ECO:0000256|HAMAP-Rule:MF_00996};
DE   AltName: Full=Menaquinone biosynthetic enzyme MqnD {ECO:0000256|HAMAP-Rule:MF_00996};
GN   Name=mqnD {ECO:0000256|HAMAP-Rule:MF_00996};
GN   OrderedLocusNames=Franean1_0151 {ECO:0000313|EMBL:ABW09618.1};
OS   Frankia sp. (strain EAN1pec).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW09618.1, ECO:0000313|Proteomes:UP000001313};
RN   [1] {ECO:0000313|Proteomes:UP000001313}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EAN1pec {ECO:0000313|Proteomes:UP000001313};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Catalyzes the conversion of cyclic dehypoxanthine
CC       futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step
CC       in the biosynthesis of menaquinone (MK, vitamin K2).
CC       {ECO:0000256|HAMAP-Rule:MF_00996}.
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00996}.
CC   -!- SIMILARITY: Belongs to the MqnA/MqnD family. MqnD subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00996}.
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DR   EMBL; CP000820; ABW09618.1; -; Genomic_DNA.
DR   RefSeq; WP_012157595.1; NC_009921.1.
DR   STRING; 298653.Franean1_0151; -.
DR   EnsemblBacteria; ABW09618; ABW09618; Franean1_0151.
DR   KEGG; fre:Franean1_0151; -.
DR   eggNOG; ENOG4105E63; Bacteria.
DR   eggNOG; COG2107; LUCA.
DR   HOGENOM; HOG000013596; -.
DR   KO; K11785; -.
DR   OMA; RGCGPLV; -.
DR   OrthoDB; 1107067at2; -.
DR   BioCyc; FSP298653:G1G9X-149-MONOMER; -.
DR   UniPathway; UPA00079; -.
DR   Proteomes; UP000001313; Chromosome.
DR   GO; GO:0016830; F:carbon-carbon lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00996; MqnD; 1.
DR   InterPro; IPR003773; Menaquinone_biosynth.
DR   InterPro; IPR030869; MqnD.
DR   PANTHER; PTHR37167; PTHR37167; 1.
DR   Pfam; PF02621; VitK2_biosynth; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8LCH9.
DR   SWISS-2DPAGE; A8LCH9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001313};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00996};
KW   Menaquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_00996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001313}.
FT   REGION       69     71       Substrate binding. {ECO:0000256|HAMAP-
FT                                Rule:MF_00996}.
FT   REGION      120    121       Substrate binding. {ECO:0000256|HAMAP-
FT                                Rule:MF_00996}.
FT   ACT_SITE    161    161       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00996}.
SQ   SEQUENCE   293 AA;  30251 MW;  D62C5D3412B80256 CRC64;
     MSTPPIGSEG GAPAPDQLTL AISPCPNDTF AFHALIHGLV PGAPAVSTTF ADIDVLNARA
     ADGRDDLVKV SYAALPWLLD RYSLLTAGGA LGRGCGPLVL TAGRTDLRDA SVAIPGTRTT
     AYLLFRLWAE QLGIGSINVV PFDRIMPAVR DGQYDAGLVI HESRFTYPSY GLTAVADLGD
     WWEGRTGLPI PLGAIVARRG LDTAALSAAV RASVAAAFAD RAASATFVIE HAQEMAPEVA
     NAHIELYVND FTLDLGDEGL AAVQELLGRA AAAGLVPELP AGALTATALA TGA
//

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