(data stored in SCRATCH zone)

SWISSPROT: A8LGG3_FRASN

ID   A8LGG3_FRASN            Unreviewed;       398 AA.
AC   A8LGG3;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   08-MAY-2019, entry version 57.
DE   RecName: Full=Bcr/CflA family efflux transporter {ECO:0000256|RuleBase:RU365088};
GN   OrderedLocusNames=Franean1_0437 {ECO:0000313|EMBL:ABW09902.1};
OS   Frankia sp. (strain EAN1pec).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW09902.1, ECO:0000313|Proteomes:UP000001313};
RN   [1] {ECO:0000313|Proteomes:UP000001313}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EAN1pec {ECO:0000313|Proteomes:UP000001313};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU365088}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU365088}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Bcr/CmlA
CC       family. {ECO:0000256|RuleBase:RU365088}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU365088}.
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DR   EMBL; CP000820; ABW09902.1; -; Genomic_DNA.
DR   RefSeq; WP_012157878.1; NC_009921.1.
DR   STRING; 298653.Franean1_0437; -.
DR   EnsemblBacteria; ABW09902; ABW09902; Franean1_0437.
DR   KEGG; fre:Franean1_0437; -.
DR   eggNOG; ENOG4105C2C; Bacteria.
DR   eggNOG; ENOG410XNNX; LUCA.
DR   HOGENOM; HOG000143170; -.
DR   KO; K07552; -.
DR   OMA; ITVIIME; -.
DR   OrthoDB; 1452500at2; -.
DR   BioCyc; FSP298653:G1G9X-433-MONOMER; -.
DR   Proteomes; UP000001313; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015238; F:drug transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004812; Efflux_drug-R_Bcr/CmlA.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00710; efflux_Bcr_CflA; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8LGG3.
DR   SWISS-2DPAGE; A8LGG3.
KW   Cell membrane {ECO:0000256|RuleBase:RU365088};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001313};
KW   Membrane {ECO:0000256|RuleBase:RU365088};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001313};
KW   Transmembrane {ECO:0000256|RuleBase:RU365088};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU365088};
KW   Transport {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM     40     61       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM     73     92       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM     98    119       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    131    149       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    161    181       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    207    225       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    245    266       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    273    294       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    300    322       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    334    358       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   TRANSMEM    364    383       Helical. {ECO:0000256|RuleBase:RU365088}.
FT   DOMAIN        7    387       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   398 AA;  40909 MW;  C8764E319AB08DF8 CRC64;
     MNSARRTLLV LGFLVALGPF TVDFYIPAFP LVQADFGTSA AAVQLTLTAT TIGFALGQLA
     IGPWSDSIGR RRPLLVATAL HVAGSLGVAA APTVEVMLVF RLLQGAGAAG SGVVALAMVR
     DLFDGALFVR MAARLAVVTG LAPVVAPFAG SLMLSHMSWR GLFVCIALYG LAVLAVAAFL
     VRETAPLVRR AGAPLGRYRV LVTDRGFVGA ALAGGLLVSS VFTYMSSSSF LFQETYGLSA
     QRYSLVFAAN AVGFVIGAQT SARLVTRIGP RRLLRYVLPS LGFLGFTLLL AAFAGENVVV
     VTFVTALYFL LAGAVGPCLQ VIGMAPHGER AGTAAALMGA ANFGLAGATA PVAGLLGVGS
     IGPIGLVMGL TMTVAVVVFR VLARDRREAR AGAPSPVP
//

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