(data stored in ACNUC8465 zone)

SWISSPROT: A8WRM6_CAEBR

ID   A8WRM6_CAEBR            Unreviewed;       363 AA.
AC   A8WRM6;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 2.
DT   11-DEC-2019, entry version 86.
DE   SubName: Full=Protein CBR-MKK-4 {ECO:0000313|EMBL:CAP23134.2};
GN   Name=mkk-4 {ECO:0000313|WormBase:CBG01940};
GN   Synonyms=Cbr-mkk-4 {ECO:0000313|EMBL:CAP23134.2};
GN   ORFNames=CBG01940 {ECO:0000313|WormBase:CBG01940}, CBG_01940
GN   {ECO:0000313|EMBL:CAP23134.2};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP23134.2, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP23134.2, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP23134.2,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC       {ECO:0000256|RuleBase:RU000304}.
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DR   EMBL; HE601451; CAP23134.2; -; Genomic_DNA.
DR   STRING; 6238.CBG01940; -.
DR   EnsemblMetazoa; CBG01940.1; CBG01940.1; WBGene00025104.
DR   WormBase; CBG01940; CBP29973; WBGene00025104; Cbr-mkk-4.
DR   eggNOG; KOG0984; Eukaryota.
DR   eggNOG; ENOG410XT3F; LUCA.
DR   HOGENOM; HOG000234206; -.
DR   InParanoid; A8WRM6; -.
DR   OMA; XRIRSTV; -.
DR   OrthoDB; 688282at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008545; F:JUN kinase kinase activity; IBA:GO_Central.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IBA:GO_Central.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0007257; P:activation of JUN kinase activity; IBA:GO_Central.
DR   GO; GO:0000187; P:activation of MAPK activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8WRM6.
DR   SWISS-2DPAGE; A8WRM6.
KW   ATP-binding {ECO:0000256|RuleBase:RU000304};
KW   Kinase {ECO:0000256|RuleBase:RU000304};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
KW   Transferase {ECO:0000256|RuleBase:RU000304}.
FT   DOMAIN          66..330
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  41158 MW;  410E6E8E5648F078 CRC64;
     MVQEDDDTSR ISMSLNPSLS NRPNTLSVNG NNEKAIPEEN VLRSLSTGTL KYPEDEHFYT
     FNSAHLQDLG AIGNGNFGTV YKMRHRETGK LLAVKRIRCN NIDQREQIRL LREHDTIVKS
     EKGPNIVKFY GAIFSEGDCW ICMELMDISM DLLYRRVYNV KGSRLNENVI GHITVCTVDA
     LDYLKKELKI IHRDVKPSNI LVDGHGSVKL CDFGICGELE DSVVKTHDAG CQPYLAPERI
     TSSDKYDVRS DVWSLGITLY EIATGRFPYP QWNSVFEQIA AVVSGDPPML SPDTGDFSYS
     LPLIKFINTC LMKDRRHRPK YDTLKNFDFY RIYARGGPEI EEAKEILGVE AIDAREHPID
     IVG
//

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