(data stored in SCRATCH zone)

SWISSPROT: A8WWG2_CAEBR

ID   A8WWG2_CAEBR            Unreviewed;      2120 AA.
AC   A8WWG2;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 2.
DT   11-DEC-2019, entry version 82.
DE   RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE            Short=PARP {ECO:0000256|RuleBase:RU362114};
DE            EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
GN   Name=Cbr-pme-1 {ECO:0000313|EMBL:CAP24971.2};
GN   ORFNames=CBG_04221 {ECO:0000313|EMBL:CAP24971.2};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP24971.2, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP24971.2, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP24971.2,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
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DR   EMBL; HE600926; CAP24971.2; -; Genomic_DNA.
DR   STRING; 6238.CBG04221; -.
DR   eggNOG; KOG1037; Eukaryota.
DR   eggNOG; ENOG410XP18; LUCA.
DR   InParanoid; A8WWG2; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IBA:GO_Central.
DR   GO; GO:1990404; F:protein ADP-ribosylase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006302; P:double-strand break repair; IBA:GO_Central.
DR   GO; GO:0070212; P:protein poly-ADP-ribosylation; IBA:GO_Central.
DR   Gene3D; 1.20.142.10; -; 1.
DR   Gene3D; 2.20.140.10; -; 1.
DR   Gene3D; 2.20.25.630; -; 1.
DR   Gene3D; 3.30.1740.10; -; 1.
DR   InterPro; IPR012982; PADR1.
DR   InterPro; IPR038650; PADR1_dom_sf.
DR   InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR   InterPro; IPR004102; Poly(ADP-ribose)pol_reg_dom.
DR   InterPro; IPR036616; Poly(ADP-ribose)pol_reg_dom_sf.
DR   InterPro; IPR036930; WGR_dom_sf.
DR   InterPro; IPR008893; WGR_domain.
DR   InterPro; IPR001510; Znf_PARP.
DR   InterPro; IPR036957; Znf_PARP_sf.
DR   Pfam; PF08063; PADR1; 1.
DR   Pfam; PF00644; PARP; 1.
DR   Pfam; PF02877; PARP_reg; 1.
DR   Pfam; PF05406; WGR; 1.
DR   Pfam; PF00645; zf-PARP; 1.
DR   SMART; SM01335; PADR1; 1.
DR   SMART; SM00773; WGR; 1.
DR   SMART; SM01336; zf-PARP; 2.
DR   SUPFAM; SSF142921; SSF142921; 1.
DR   SUPFAM; SSF47587; SSF47587; 1.
DR   PROSITE; PS51060; PARP_ALPHA_HD; 1.
DR   PROSITE; PS51059; PARP_CATALYTIC; 1.
DR   PROSITE; PS50064; PARP_ZN_FINGER_2; 1.
PE   4: Predicted;
DR   PRODOM; A8WWG2.
DR   SWISS-2DPAGE; A8WWG2.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU362114};
KW   Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|RuleBase:RU362114};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Transferase {ECO:0000256|RuleBase:RU362114};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        2099..2119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..61
FT                   /note="PARP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50064"
FT   DOMAIN          573..691
FT                   /note="PARP alpha-helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51060"
FT   DOMAIN          704..953
FT                   /note="PARP catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51059"
FT   COILED          242..262
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1078..1119
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1128..1155
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1216..1243
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1276..1310
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1336..1363
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1437..1492
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1510..1544
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1623..1657
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1679..1699
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1714..1755
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1785..1876
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1884..1911
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1930..1950
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1962..1999
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2003..2023
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2025..2052
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2120 AA;  242915 MW;  A34719DEF40B8FCC CRC64;
     MSLHQPSIFF DGTMDSWFHF ECFWQNLAHG RHEINISSIK GVDWLRWEDQ ERLRDRVQKF
     RDPHFPPKLY FNTVSLSALK TDKSATNRGK CVKCGVNFEK DEIKVIHKSK NLHFKCHLEG
     FEKVEGTLND VPGWSDYEDC WKNRVSESCL EIMKAKGPAE PNQPKVVLVV DGIEEGNLET
     TPDSASKVTT TIQASTTASS VVLDDDKLPL PDVPSTSIAG QKRHAEPEII IQDEEETDAS
     KKRRLARETK KAELQKARMK KQADQLWACR QLFEKLSGSE RLAVLQINGQ DIPEGQDPTA
     LVIDRLADNA TFGAPIGCQK CKNGKVVYNS SRRTYTCTGY ATEYSKCTFE TKNPIRTPFK
     TTPRLLEKCQ GSVLFNVMCE RLYIDVEEAE EVVKVDRRKS KGGVRGEQFI YAAEAFDMNN
     HVPIKINDLT STNTHIIKNG TVVDAKFRYA DRCHVYRSEV DGALYQATLS FTDLTQNKNS
     FYKIQLLKDD TREIYYVFRS WGRVGTEVGG FMDDSFAKEA AIQKFEEIFL EKTKNEWMFR
     KHFRKMPGAF SFVETDYSEF DQLKEQDIIP GSRTLLPRAV KEIVMSIFDI ENMKSALKSF
     EMDVNKMPLG RLSHKQINQA FAVLNDLSDL LIDVPVDEDR ILDCTNKFYT IIPHNFGMKV
     PEPIDSFHKI KEKNNMLNAL LEIKFAYDQI CGGDSTPTVT IGIDPVDVNY QKLKCKMNPI
     EKGCNEWKMI QEYITNTKGS THNIKVELMD ILMVDRENES NKFKRHIGNR KLLWHGSGKM
     NFAGILGQGL RIAPPEAPVS GYMFGKGVYF ADMFSKSFFY CRVNASKDEA YLLLCDVALG
     NMAEKMDAVS VTKNTLPKGT SSVKGIGREC PNPIGDYNHA DGYVVPKGPT HVQLTGKHGT
     DFRLLYNEYV REKCFLNRKH LTIKHYRYIV YDVDQVQLKY LVRVKCLQAC NNIARQIESI
     MGRKNKTKLL KHGSQSLNAS TIIESDGRSS SNDSHQVEFE ALSSQLREFV TSGSSPHTHK
     DVARLYSSLE KKDAELIVAK QLIKTLKATA PADHNGDGDS LFTIREDNLS ESANGHNCTN
     IIEELDRVTK QNDDLVKERE KLADQLNDTE NRAIQLEGNQ MIFCKIFHMR ISVEVKSLED
     NLDQTNRTLE EGRQTSEAVI GELKKSLMSA SQTVETLQSD IEAHKSSYRT VCSDLEIVRE
     RSVRLEKDML QSVHLQKETS DKLEQAQQEI SSLKAAMVKQ NVDFSNSMNQ LVVDREKLET
     RYDRINNGVQ LIKKDFDEVK KNLVESNGKI KELQQQLASS KADVKHYRDN EEACRKYIKK
     LEENDHAADA LAKETILELQ DKYKLQTEKM KLAEDQLSKK EDLEASLVKD LQEEFQFNGS
     IDLVSAVTQL RENFKKEQRK QVFQSAALEG KDVAYQKLLK QNSSLLETIS KHDAQRSEVM
     EEEREKFQEE LNALKKANRK LKKEKDHSLK RLKNLLTKNS DLLDHSKALE EKLNHSASNE
     SMSSVNSETL DSLEDSIKIL KCTLESNENK LSEVSKQLVQ KEEENLDLHR TVVAYKSKIA
     GCEQEHIKSQ KQVSTMECRL AELQRSSDLQ LKRYEEDLSA VREKLGSSDA ALEVQQELNC
     KLSAHTEELK QKYDDESNRL EKEVSELMEK IVLQESHKKQ QDALISDAEV KICELSDKIK
     SLDAQLKTIQ EKLDEQQKFS QEIEEGKMKV EGVLSSTMEE KQKLLEETER LTKKLEEFEE
     SRKETESGLA EINHQLANEA EALRTQIMAQ DLKIEKLSSS RDKVVEDLFR QFDQKEKEYE
     KLLQSEKAKF EILGKRLEEK TEESSEKVRR LKEKEITIEE LKVEKEKTLL ETQEKVQQKE
     NDLMKMVAEK ASLESQIESF KLLAEDRQTE IENLIKEKHE LALKQQNSET EMAKIHKKLQ
     DALSPKKDKV LQLENRLEVI QTAAKAQNKR LEDELSSTMA LLQLSTEKTD CLEKKIVELQ
     QQTDELQQKN IELDAELAKS TRLKEVVADL EKINKDIQVE NAEERTGLVN ELIDAKQKLA
     ECETQISDLQ SHSMVRSDQT EVNQFKQTRL SEMHTDTLFP SMDPAVRQLV ILLSRNRNYS
     YGVLGLVIYG FLVHLYILCK
//

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