(data stored in ACNUC15465 zone)

SWISSPROT: GAGE5_HUMAN

ID   GAGE5_HUMAN             Reviewed;         117 AA.
AC   Q13069; Q6FG72;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   12-APR-2017, entry version 113.
DE   RecName: Full=G antigen 5;
DE            Short=GAGE-5;
DE   AltName: Full=Cancer/testis antigen 4.5;
DE            Short=CT4.5;
GN   Name=GAGE5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Melanoma;
RX   PubMed=7544395; DOI=10.1084/jem.182.3.689;
RA   van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S.,
RA   Boon T.;
RT   "A new family of genes coding for an antigen recognized by autologous
RT   cytolytic T lymphocytes on a human melanoma.";
RL   J. Exp. Med. 182:689-698(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA   Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA   Korn B., Zuo D., Hu Y., LaBaer J.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   CHARACTERIZATION OF ANTIGENIC PEPTIDES.
RX   PubMed=10397259;
RA   De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C.,
RA   Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P.,
RA   Van den Eynde B., Boon T., van der Bruggen P.;
RT   "Characterization of the GAGE genes that are expressed in various
RT   human cancers and in normal testis.";
RL   Cancer Res. 59:3157-3165(1999).
RN   [5]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the
RT   inclusion of newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
CC   -!- INTERACTION:
CC       Q53SE7:FLJ13057; NbExp=3; IntAct=EBI-745702, EBI-10172181;
CC       Q96IK5:GMCL1; NbExp=3; IntAct=EBI-745702, EBI-2548508;
CC       Q8NEA9:GMCL1P1; NbExp=6; IntAct=EBI-745702, EBI-745707;
CC       Q9NYB0:TERF2IP; NbExp=2; IntAct=EBI-745702, EBI-750109;
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of tumor tissues but
CC       not in normal tissues, except testis.
CC   -!- MISCELLANEOUS: This gene belongs to a family of genes organized in
CC       clustered repeats. They have a high degree of predicted sequence
CC       identity, but differ by scattered single nucleotide substitution.
CC       Their sequences contain either the antigenic peptide YYWPRPRRY or
CC       YRPRPRRY which is recognized by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made
CC       impossible to separate products of paralogous genes from polymorph
CC       products. PubMed:18179644 presented a new GAGE gene nomenclature
CC       based on the identified genes and their products. {ECO:0000305}.
DR   EMBL; U19146; AAA82748.1; -; mRNA.
DR   EMBL; CR542236; CAG47032.1; -; mRNA.
DR   EMBL; BC024914; AAH24914.1; -; mRNA.
DR   RefSeq; NP_001465.1; NM_001474.1.
DR   RefSeq; NP_001466.1; NM_001475.1.
DR   UniGene; Hs.460641; -.
DR   UniGene; Hs.695912; -.
DR   UniGene; Hs.722100; -.
DR   BioGrid; 108850; 3.
DR   IntAct; Q13069; 4.
DR   MINT; MINT-1453280; -.
DR   iPTMnet; Q13069; -.
DR   PhosphoSitePlus; Q13069; -.
DR   MaxQB; Q13069; -.
DR   PaxDb; Q13069; -.
DR   PRIDE; Q13069; -.
DR   TopDownProteomics; Q13069; -.
DR   DNASU; 2576; -.
DR   GeneID; 2576; -.
DR   GeneID; 2577; -.
DR   KEGG; hsa:2576; -.
DR   KEGG; hsa:2577; -.
DR   CTD; 2576; -.
DR   CTD; 2577; -.
DR   DisGeNET; 2543; -.
DR   DisGeNET; 2576; -.
DR   DisGeNET; 2577; -.
DR   GeneCards; GAGE5; -.
DR   HGNC; HGNC:4102; GAGE5.
DR   HPA; HPA043232; -.
DR   MIM; 300598; gene.
DR   neXtProt; NX_Q13069; -.
DR   PharmGKB; PA28517; -.
DR   eggNOG; ENOG410KIHC; Eukaryota.
DR   eggNOG; ENOG4110Q8D; LUCA.
DR   HOVERGEN; HBG056227; -.
DR   InParanoid; Q13069; -.
DR   PRO; PR:Q13069; -.
DR   Proteomes; UP000005640; Unplaced.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q13069.
DR   SWISS-2DPAGE; Q13069.
KW   Complete proteome; Reference proteome.
FT   CHAIN         1    117       G antigen 5.
FT                                /FTId=PRO_0000148343.
FT   CONFLICT     23     23       V -> M (in Ref. 2; CAG47032).
FT                                {ECO:0000305}.
SQ   SEQUENCE   117 AA;  12924 MW;  234A865E2ECDDD06 CRC64;
     MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
     DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC
//

If you have problems or comments...

PBIL Back to PBIL home page