(data stored in ACNUC1829 zone)

SWISSPROT: CD37_MOUSE

ID   CD37_MOUSE              Reviewed;         281 AA.
AC   Q61470;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   05-JUL-2017, entry version 123.
DE   RecName: Full=Leukocyte antigen CD37;
DE   AltName: CD_antigen=CD37;
GN   Name=Cd37;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=129/Sv; TISSUE=Liver;
RX   PubMed=8845018; DOI=10.1016/0161-5890(96)84612-8;
RA   Tomlinson M.G., Wright M.D.;
RT   "Characterisation of mouse CD37: cDNA and genomic cloning.";
RL   Mol. Immunol. 33:867-872(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Interacts with SCIMP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000305}.
DR   EMBL; U18372; AAB39500.1; -; Genomic_DNA.
DR   EMBL; U18367; AAB39500.1; JOINED; Genomic_DNA.
DR   EMBL; U18368; AAB39500.1; JOINED; Genomic_DNA.
DR   EMBL; U18369; AAB39500.1; JOINED; Genomic_DNA.
DR   EMBL; U18370; AAB39500.1; JOINED; Genomic_DNA.
DR   EMBL; U18371; AAB39500.1; JOINED; Genomic_DNA.
DR   EMBL; BC019402; AAH19402.1; -; mRNA.
DR   CCDS; CCDS21237.1; -.
DR   RefSeq; NP_031671.1; NM_007645.4.
DR   UniGene; Mm.3689; -.
DR   ProteinModelPortal; Q61470; -.
DR   STRING; 10090.ENSMUSP00000096061; -.
DR   iPTMnet; Q61470; -.
DR   PhosphoSitePlus; Q61470; -.
DR   SwissPalm; Q61470; -.
DR   EPD; Q61470; -.
DR   MaxQB; Q61470; -.
DR   PaxDb; Q61470; -.
DR   PRIDE; Q61470; -.
DR   Ensembl; ENSMUST00000098461; ENSMUSP00000096061; ENSMUSG00000030798.
DR   GeneID; 12493; -.
DR   KEGG; mmu:12493; -.
DR   UCSC; uc009guh.1; mouse.
DR   CTD; 951; -.
DR   MGI; MGI:88330; Cd37.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00880000137858; -.
DR   HOGENOM; HOG000230651; -.
DR   HOVERGEN; HBG002324; -.
DR   InParanoid; Q61470; -.
DR   KO; K06475; -.
DR   PhylomeDB; Q61470; -.
DR   TreeFam; TF352892; -.
DR   PRO; PR:Q61470; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000030798; -.
DR   CleanEx; MM_CD37; -.
DR   ExpressionAtlas; Q61470; baseline and differential.
DR   Genevisible; Q61470; MM.
DR   GO; GO:0070062; C:extracellular exosome; ISO:MGI.
DR   GO; GO:0001772; C:immunological synapse; ISO:MGI.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; ISO:MGI.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0042832; P:defense response to protozoan; IGI:MGI.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.
DR   GO; GO:0030886; P:negative regulation of myeloid dendritic cell activation; IGI:MGI.
DR   GO; GO:0002639; P:positive regulation of immunoglobulin production; IMP:MGI.
DR   GO; GO:0050688; P:regulation of defense response to virus; IGI:MGI.
DR   GO; GO:0002920; P:regulation of humoral immune response; IMP:MGI.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 2.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q61470.
DR   SWISS-2DPAGE; Q61470.
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    281       Leukocyte antigen CD37.
FT                                /FTId=PRO_0000219210.
FT   TOPO_DOM      1     17       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     18     38       Helical. {ECO:0000255}.
FT   TOPO_DOM     39     59       Extracellular. {ECO:0000255}.
FT   TRANSMEM     60     74       Helical. {ECO:0000255}.
FT   TOPO_DOM     75     85       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     86    111       Helical. {ECO:0000255}.
FT   TOPO_DOM    112    241       Extracellular. {ECO:0000255}.
FT   TRANSMEM    242    266       Helical. {ECO:0000255}.
FT   TOPO_DOM    267    281       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD    170    170       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    183    183       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    188    188       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   281 AA;  31852 MW;  5B0E11B3B9CCA22D CRC64;
     MSAQESCLSL IKYFLFVFNL FFFVLGGLIF CFGTWILIDK TSFVSFVGLS FVPLQTWSKV
     LAVSGVLTMA LALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRVRLERRVQ
     ELVLRTIQSY RTNPDETAAE ESWDYAQFQL RCCGWQSPRD WNKAQMLKAN ESEEPFVPCS
     CYNSTATNDS TVFDKLFFSQ LSRLGPRAKL RQTADICALP AKAHIYREGC AQSLQKWLHN
     NIISIVGICL GVGLLELGFM TLSIFLCRNL DHVYDRLARY R
//

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