(data stored in SCRATCH9089 zone)

SWISSPROT: URAA_PASMU

ID   URAA_PASMU              Reviewed;         417 AA.
AC   Q9CPL9;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   11-DEC-2019, entry version 109.
DE   RecName: Full=Probable uracil permease;
DE   AltName: Full=Uracil transporter;
GN   Name=uraA; OrderedLocusNames=PM0018;
OS   Pasteurella multocida (strain Pm70).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=272843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- FUNCTION: Transport of uracil in the cell. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the xanthine/uracil permease family.
CC       Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.
CC       {ECO:0000305}.
DR   EMBL; AE004439; AAK02102.1; -; Genomic_DNA.
DR   RefSeq; WP_010906431.1; NC_002663.1.
DR   SMR; Q9CPL9; -.
DR   PRIDE; Q9CPL9; -.
DR   EnsemblBacteria; AAK02102; AAK02102; PM0018.
DR   KEGG; pmu:PM0018; -.
DR   PATRIC; fig|272843.6.peg.18; -.
DR   eggNOG; ENOG4105C2W; Bacteria.
DR   eggNOG; COG2233; LUCA.
DR   HOGENOM; HOG000038200; -.
DR   KO; K02824; -.
DR   OMA; VYSVYVI; -.
DR   BioCyc; PMUL272843:G1FZ8-20-MONOMER; -.
DR   Proteomes; UP000000809; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015210; F:uracil transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR029935; Uracil_permease.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   InterPro; IPR006043; Xant/urac/vitC.
DR   PANTHER; PTHR11119:SF49; PTHR11119:SF49; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   TIGRFAMs; TIGR00801; ncs2; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q9CPL9.
DR   SWISS-2DPAGE; Q9CPL9.
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..417
FT                   /note="Probable uracil permease"
FT                   /id="PRO_0000165961"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        14..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        38..41
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        42..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        62..64
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        65..81
FT                   /note="Discontinuously helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        83..90
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        112..123
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        124..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        146..154
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        155..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        171..177
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        199..223
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        224..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        248..260
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        261..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        281..297
FT                   /note="Discontinuously helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        298..300
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        301..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        319..331
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        332..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        354..364
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   INTRAMEM        365..400
FT                   /note="Discontinuously helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        401..416
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   BINDING         73
FT                   /note="Uracil; via amide nitrogen"
FT                   /evidence="ECO:0000250"
FT   BINDING         240
FT                   /note="Uracil"
FT                   /evidence="ECO:0000250"
FT   BINDING         289
FT                   /note="Uracil"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   417 AA;  43933 MW;  494D97CEA35CC6C1 CRC64;
     MTNQNPPVLL EQNHAKQAFV GLQMLFVAFG ALVLVPLITG LNANTALLTA GIGTLLFQLC
     TGRQVPIFLA SSFAFIAPIQ YGVTTWGIAT TMGGLVFTGL VYFALSTLVK IKGAGALQKV
     FPPVVVGPVI IIIGMGLAPV AVDMALGKNS TYQYNDAVFV SMATLLTTLG VAVFAKGMMK
     LIPIMFGIVV GYILCLFLGL INFQPVIDAP WFSVPEITTP EFKLEAILYL LPIAIAPAVE
     HVGGIMAISS VTGKDFLQKP GLHRTLLGDG IATSAASFLG GPPNTTYAEV TGAVMLTRNF
     NPKIMTWAAV WAIAISFCGK VGAFLSTIPT IVMGGIMMLV FGSIAVVGMS TLIRGKVDVT
     EARNLCIISV VMTFGIGGMF VNFGEVSLKG ISLCAVVAIL LNLILPKAKN TPIEENR
//

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