(data stored in SCRATCH9089 zone)

SWISSPROT: MUKB_PASMU

ID   MUKB_PASMU              Reviewed;        1495 AA.
AC   Q9CN36;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   11-DEC-2019, entry version 111.
DE   RecName: Full=Chromosome partition protein MukB {ECO:0000255|HAMAP-Rule:MF_01800};
DE   AltName: Full=Structural maintenance of chromosome-related protein {ECO:0000255|HAMAP-Rule:MF_01800};
GN   Name=mukB {ECO:0000255|HAMAP-Rule:MF_01800}; OrderedLocusNames=PM0609;
OS   Pasteurella multocida (strain Pm70).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=272843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC       and cell cycle progression. Functions as a homodimer, which is
CC       essential for chromosome partition. Involved in negative DNA
CC       supercoiling in vivo, and by this means organize and compact
CC       chromosomes. May achieve or facilitate chromosome segregation by
CC       condensation DNA from both sides of a centrally located replisome
CC       during cell division. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC       terminal region. Interacts, and probably forms a ternary complex, with
CC       MukE and MukF via its C-terminal region. The complex formation is
CC       stimulated by calcium or magnesium. Interacts with tubulin-related
CC       protein FtsZ. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01800}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC       coiled coil regions, allows the homodimerization, forming a V-shaped
CC       homodimer. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SIMILARITY: Belongs to the SMC family. MukB subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
DR   EMBL; AE004439; AAK02693.1; -; Genomic_DNA.
DR   RefSeq; WP_010906751.1; NC_002663.1.
DR   SMR; Q9CN36; -.
DR   PRIDE; Q9CN36; -.
DR   EnsemblBacteria; AAK02693; AAK02693; PM0609.
DR   KEGG; pmu:PM0609; -.
DR   PATRIC; fig|272843.6.peg.617; -.
DR   eggNOG; ENOG4105DUC; Bacteria.
DR   eggNOG; COG3096; LUCA.
DR   HOGENOM; HOG000278243; -.
DR   KO; K03632; -.
DR   OMA; FIAVYQH; -.
DR   BioCyc; PMUL272843:G1FZ8-642-MONOMER; -.
DR   Proteomes; UP000000809; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1060.30; -; 1.
DR   HAMAP; MF_01800; MukB; 1.
DR   InterPro; IPR012090; MukB.
DR   InterPro; IPR032520; MukB_hinge.
DR   InterPro; IPR042501; MukB_hinge_sf.
DR   InterPro; IPR007406; MukB_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04310; MukB; 1.
DR   Pfam; PF16330; MukB_hinge; 1.
DR   PIRSF; PIRSF005246; MukB; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
DR   PRODOM; Q9CN36.
DR   SWISS-2DPAGE; Q9CN36.
KW   ATP-binding; Cell cycle; Cell division; Chromosome partition; Coiled coil;
KW   Cytoplasm; DNA condensation; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..1495
FT                   /note="Chromosome partition protein MukB"
FT                   /id="PRO_0000068223"
FT   NP_BIND         60..67
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   REGION          692..809
FT                   /note="Flexible hinge"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          322..693
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          861..1140
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          1233..1289
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
SQ   SEQUENCE   1495 AA;  171263 MW;  78C5FDBC1D48CE18 CRC64;
     MSEELALENL EHVETSVPHT VFSHANSAPR GKFRSLTLIN WNGFFARTFD LDELVTTLSG
     GNGAGKSTTM AGFVTALIPD LTLLHFRNTT EAGATSGSRD KGLHGKLRPG VCYAALDTIN
     SRNQRVIVGA RLQQVAGRDK KVDIKTFSIQ GLNLAENPTT IFTDVVNERQ ARVLTLNELK
     EKIEQAGAQF KQYHSITDYH AMMFDLGIIP KRLRSSSDRS KFYKLIEASL YGGISSAITR
     SLRDYLLPEN LGVRKAFQDM ESALRENRMT LEAIKVTQAD RDLFKHLITE TSNYVASDYM
     RHANERRGNI ESAVRFRQDW YRARTEQHLS QQRLVELSRE AAELAENEKT LEVDHQSAVD
     YLNLVLNALR HQEKIARYQD DVAEITARLE EQKMVVETAT EQLEESQVQV EQVEQEVDQI
     RAQLADYQQA LDAQQTRALQ YQQAIAALEK AKTLCGLADL GVKNVEAYHD EFAAHAESLT
     EQVLELEQRM SISDAAKSQF DKAYQLVCKV AGEIPRSTAF EQAKVLLRDY PTQKVQAQQT
     SQLRAKLHEL EQRYAQQQSA VRLLKEFNQR ANVSLEDAEA LEAYHAEQEA LLEDVSAELS
     EQVEQRSTLR QKREQLSALY QDNAKKAPAW LTAQAALERL QDQSGETFAD SQDVMQFMQA
     QLVKERELTI ERDQLEQQRQ QLEAQISRLS QPDGSEDARL NVLAERFGGV LLSELYDDVP
     IEDAPYFSAL YGPARHAIVV RDLDAVKGQL AQLEECPDDL YLIEGDPTAF DDSVLSAQEL
     AHGVVVQVSD RELRYSKFPE IPLFGRAARE QYLEALQQQR DDVTEQHAQR AFDVQKCQRL
     HEHFSQFVGL HLALAFQPNP EDVMAEIQQQ RNEIERELNQ FVTTEQQLRI QLDYAKEKMQ
     LLNKLIPQLN LIADESLIDR VEECREQLDI AEQDELFIRQ YGATLSQLEP IANTLQSDPE
     HYERLKADYE QAISQQKQVQ QRLFALADVL QRKAHFAYEE RVQTENTDLN EQLRAKLDSL
     QQQREVQKAQ LQQKQQQFTN YNRVYIELQT SFNNKMQMLQ ELLQEVGELG VRADQGAEER
     AKQRRDELHQ VLSDTRQRRH YVEKQLTLIE SEAQSLNARI RKAERDYKTQ RELVVAAKVS
     WCVVMRLSRG SDVEKRLNRR EFAYLSADEL RSMSDKALGA LRTAVADNEY LRDSLRLSED
     NRKPENKVRF FIAVYQHLRE RIRQDIIKTD DPIDAIEQME IELSRLTDEL TRREQKLAIS
     SESVANIMRK TIQREQNRIR MLNQGLQNIA FGQVKSVRLV VNIRDTHAML LDALSGTQEE
     YQDLFTDQRM TFSEAIAKLY QRLNPHIDMG QRTAQTIGEE LLDYRNYLDL EVEVYRGADG
     WLRAESGALS TGEAIGTGMS ILLMVVQSWE EESRRIRGKD IVPCRLLFLD EAARLDAKSI
     STLFELCERL DMQLLIAAPE NISPEKGTTY KLVRKIAGNQ EHVHVVGLRG FGATA
//

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