(data stored in ACNUC7421 zone)

SWISSPROT: RIHC_SALTY

ID   RIHC_SALTY              Reviewed;         306 AA.
AC   Q8ZRY7;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   11-DEC-2019, entry version 85.
DE   RecName: Full=Non-specific ribonucleoside hydrolase RihC {ECO:0000255|HAMAP-Rule:MF_01432};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01432};
DE   AltName: Full=Purine/pyrimidine ribonucleoside hydrolase {ECO:0000255|HAMAP-Rule:MF_01432};
GN   Name=rihC {ECO:0000255|HAMAP-Rule:MF_01432}; OrderedLocusNames=STM0051;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Hydrolyzes both purine and pyrimidine ribonucleosides with a
CC       broad-substrate specificity. {ECO:0000255|HAMAP-Rule:MF_01432}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihC subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01432}.
DR   EMBL; AE006468; AAL19015.1; -; Genomic_DNA.
DR   RefSeq; NP_459056.1; NC_003197.2.
DR   RefSeq; WP_000127283.1; NC_003197.2.
DR   SMR; Q8ZRY7; -.
DR   PaxDb; Q8ZRY7; -.
DR   PRIDE; Q8ZRY7; -.
DR   EnsemblBacteria; AAL19015; AAL19015; STM0051.
DR   GeneID; 1251569; -.
DR   KEGG; stm:STM0051; -.
DR   PATRIC; fig|99287.12.peg.53; -.
DR   eggNOG; ENOG4105DU0; Bacteria.
DR   eggNOG; COG1957; LUCA.
DR   HOGENOM; HOG000218839; -.
DR   KO; K12700; -.
DR   OMA; TPVAEWN; -.
DR   PhylomeDB; Q8ZRY7; -.
DR   BioCyc; SENT99287:STM0051-MONOMER; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008477; F:purine nucleosidase activity; IBA:GO_Central.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006152; P:purine nucleoside catabolic process; IBA:GO_Central.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01432; Nucleosid_hydro_RihC; 1.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022976; Nucleosid_hydro_RihC_nonspecif.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8ZRY7.
DR   SWISS-2DPAGE; Q8ZRY7.
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..306
FT                   /note="Non-specific ribonucleoside hydrolase RihC"
FT                   /id="PRO_0000206837"
FT   ACT_SITE        235
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01432"
SQ   SEQUENCE   306 AA;  33122 MW;  A31A003C2894DAE2 CRC64;
     MTASLHIILD TDPGIDDAAA IAAALFAPQL DLQLITTVAG NVSVEKTTRN ALQLLHFWNS
     DIPLAQGAAT PLLRPLRDAA YVHGESGMEG YDFVDHQRQP LAKPAFIAIR DVLMNAPEPM
     TLVAIGPLTN IALLLMHYPE CACNIRRLVL MGGSAGRGNF TPNAEFNIAV DPEAAALVFR
     SGLEIVMCGL DVTNQAMLSP DFLNKLPALN RTGKMLHSLF NHYRSGSMRT GVRMHDLCAI
     AWLVRPELFT LQSCFVAVET QGQYTAGTTV VDIEGRLGQP ANAQVALALD VDGFRQWVAE
     VFAYAP
//

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