(data stored in ACNUC7421 zone)

SWISSPROT: LPTD_SALTY

ID   LPTD_SALTY              Reviewed;         786 AA.
AC   Q8ZRW0;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   11-DEC-2019, entry version 90.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=STM0093;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC       complex. Interacts with LptE and LptA. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- INTERACTION:
CC       Q8ZQZ7:lptE; NbExp=3; IntAct=EBI-16111554, EBI-16111540;
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- PTM: Contains two intramolecular disulfide bonds. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
DR   EMBL; AE006468; AAL19057.1; -; Genomic_DNA.
DR   RefSeq; NP_459098.1; NC_003197.2.
DR   RefSeq; WP_000746127.1; NC_003197.2.
DR   PDB; 4N4R; X-ray; 2.80 A; A/C=1-786.
DR   PDBsum; 4N4R; -.
DR   SMR; Q8ZRW0; -.
DR   DIP; DIP-61032N; -.
DR   IntAct; Q8ZRW0; 1.
DR   PaxDb; Q8ZRW0; -.
DR   PRIDE; Q8ZRW0; -.
DR   EnsemblBacteria; AAL19057; AAL19057; STM0093.
DR   GeneID; 1251611; -.
DR   KEGG; stm:STM0093; -.
DR   PATRIC; fig|99287.12.peg.96; -.
DR   eggNOG; ENOG4105E7H; Bacteria.
DR   eggNOG; COG1452; LUCA.
DR   HOGENOM; HOG000218450; -.
DR   KO; K04744; -.
DR   OMA; DYSHLDW; -.
DR   PhylomeDB; Q8ZRW0; -.
DR   BioCyc; SENT99287:STM0093-MONOMER; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR007543; LptD_C.
DR   InterPro; IPR005653; OstA-like_N.
DR   Pfam; PF04453; LptD; 1.
DR   Pfam; PF03968; OstA; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q8ZRW0.
DR   SWISS-2DPAGE; Q8ZRW0.
KW   3D-structure; Cell outer membrane; Disulfide bond; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   CHAIN           25..786
FT                   /note="LPS-assembly protein LptD"
FT                   /id="PRO_0000020289"
FT   DISULFID        31..726
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   DISULFID        173..727
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01411"
FT   STRAND          232..236
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   TURN            237..239
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          240..244
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          247..249
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          252..254
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          256..264
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   TURN            265..268
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          269..280
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          283..289
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          312..321
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   TURN            322..324
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          325..336
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   HELIX           339..342
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          356..365
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          368..377
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          388..400
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          403..405
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          407..424
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          426..442
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          445..457
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   HELIX           464..467
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          469..471
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          481..493
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          495..497
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   TURN            500..502
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          507..519
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          525..527
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   HELIX           540..543
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          547..552
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          557..569
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          575..588
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          605..616
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          619..631
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          634..649
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          652..661
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   HELIX           663..669
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   HELIX           672..676
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   TURN            678..682
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          684..693
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          696..698
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          700..708
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   TURN            709..712
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          713..722
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          731..742
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   TURN            743..746
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          747..751
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          754..757
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   HELIX           772..775
FT                   /evidence="ECO:0000244|PDB:4N4R"
FT   STRAND          778..780
FT                   /evidence="ECO:0000244|PDB:4N4R"
SQ   SEQUENCE   786 AA;  89872 MW;  190AA418CB852237 CRC64;
     MKKRIPTLLA TMIASALYSH QGLAADLASQ CMLGVPSYDR PLVKGDTNDL PVTINADNAK
     GNYPDDAVFT GNVDIMQGNS RLQADEVQLH QKQAEGQPEP VRTVDALGNV HYDDNQVILK
     GPKGWANLNT KDTNVWEGDY QMVGRQGRGK ADLMKQRGEN RYTILENGSF TSCLPGSDTW
     SVVGSEVIHD REEQVAEIWN ARFKVGPVPI FYSPYLQLPV GDKRRSGFLI PNAKYTTKNY
     FEFYLPYYWN IAPNMDATIT PHYMHRRGNI MWENEFRYLT QAGEGVMELD YLPSDKVYED
     DHPKEGDKHR WLFYWQHSGV MDQVWRFNVD YTKVSDSSYF NDFDSKYGSS TDGYATQKFS
     VGYAVQNFDA TVSTKQFQVF NDQNTSSYSA EPQLDVNYYH NDLGPFDTRI YGQAVHFVNT
     KDNMPEATRV HLEPTINLPL SNRWGSLNTE AKLMATHYQQ TNLDSYNSDP NNKNKLEDSV
     NRVMPQFKVD GKLIFERDMA MLAPGYTQTL EPRVQYLYVP YRDQSGIYNY DSSLLQSDYN
     GLFRDRTYGG LDRIASANQV TTGVTTRIYD DAAVERFNVS VGQIYYFTES RTGDDNIKWE
     NDDKTGSLVW AGDTYWRISE RWGLRSGVQY DTRLDSVATS SSSLEYRRDQ DRLVQLNYRY
     ASPEYIQATL PSYYSTAEQY KNGINQVGAV ASWPIADRWS IVGAYYFDTN SSKPADQMLG
     LQYNSCCYAI RVGYERKLNG WDNDKQHAIY DNAIGFNIEL RGLSSNYGLG TQEMLRSNIL
     PYQSSM
//

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