(data stored in ACNUC7421 zone)

SWISSPROT: YACG_SALTY

ID   YACG_SALTY              Reviewed;          63 AA.
AC   P67481; Q8XFY1;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   11-DEC-2019, entry version 80.
DE   RecName: Full=DNA gyrase inhibitor YacG {ECO:0000255|HAMAP-Rule:MF_00649};
GN   Name=yacG {ECO:0000255|HAMAP-Rule:MF_00649}; OrderedLocusNames=STM0138;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Inhibits all the catalytic activities of DNA gyrase by
CC       preventing its interaction with DNA. Acts by binding directly to the C-
CC       terminal domain of GyrB, which probably disrupts DNA binding by the
CC       gyrase. {ECO:0000255|HAMAP-Rule:MF_00649}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00649};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00649};
CC   -!- SUBUNIT: Interacts with GyrB. {ECO:0000255|HAMAP-Rule:MF_00649}.
CC   -!- SIMILARITY: Belongs to the DNA gyrase inhibitor YacG family.
CC       {ECO:0000255|HAMAP-Rule:MF_00649}.
DR   EMBL; AE006468; AAL19102.1; -; Genomic_DNA.
DR   RefSeq; NP_459143.1; NC_003197.2.
DR   RefSeq; WP_001286419.1; NC_003197.2.
DR   SMR; P67481; -.
DR   PaxDb; P67481; -.
DR   EnsemblBacteria; AAL19102; AAL19102; STM0138.
DR   GeneID; 1251656; -.
DR   KEGG; stm:STM0138; -.
DR   PATRIC; fig|99287.12.peg.146; -.
DR   eggNOG; ENOG41067SF; Bacteria.
DR   eggNOG; COG3024; LUCA.
DR   HOGENOM; HOG000255917; -.
DR   KO; K09862; -.
DR   OMA; FRPFCSD; -.
DR   PhylomeDB; P67481; -.
DR   BioCyc; SENT99287:STM0138-MONOMER; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0008657; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.30.50.10; -; 1.
DR   HAMAP; MF_00649; DNA_gyrase_inhibitor_YacG; 1.
DR   InterPro; IPR005584; DNA_gyrase_inhibitor_YacG.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR36150; PTHR36150; 1.
DR   Pfam; PF03884; YacG; 1.
PE   3: Inferred from homology;
DR   PRODOM; P67481.
DR   SWISS-2DPAGE; P67481.
KW   Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..63
FT                   /note="DNA gyrase inhibitor YacG"
FT                   /id="PRO_0000211724"
FT   METAL           9
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00649"
FT   METAL           12
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00649"
FT   METAL           28
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00649"
FT   METAL           32
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00649"
SQ   SEQUENCE   63 AA;  7050 MW;  739EC7618683FB5A CRC64;
     MSDVTVVNCP TCGKPVVWGE ISPFRPFCSK RCQLIDLGEW AAEEKRIASS GDQSDSDDWS
     EER
//

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