(data stored in ACNUC7421 zone)

SWISSPROT: AROP_SALTY

ID   AROP_SALTY              Reviewed;         457 AA.
AC   P0CK99; P0A187; Q8Z9F1; Q9L4I0;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   11-DEC-2019, entry version 44.
DE   RecName: Full=Aromatic amino acid transport protein AroP;
DE   AltName: Full=General aromatic amino acid permease;
GN   Name=aroP; OrderedLocusNames=STM0150;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Permease that is involved in the transport across the
CC       cytoplasmic membrane of the aromatic amino acids (phenylalanine,
CC       tyrosine, and tryptophan). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
CC       {ECO:0000305}.
DR   EMBL; AE006468; AAL19114.1; -; Genomic_DNA.
DR   RefSeq; NP_459155.1; NC_003197.2.
DR   RefSeq; WP_000969487.1; NC_003197.2.
DR   SMR; P0CK99; -.
DR   PaxDb; P0CK99; -.
DR   EnsemblBacteria; AAL19114; AAL19114; STM0150.
DR   GeneID; 1251668; -.
DR   KEGG; stm:STM0150; -.
DR   PATRIC; fig|99287.12.peg.160; -.
DR   eggNOG; ENOG4105C85; Bacteria.
DR   eggNOG; COG1113; LUCA.
DR   HOGENOM; HOG000261849; -.
DR   KO; K11734; -.
DR   OMA; IFMIVRA; -.
DR   PhylomeDB; P0CK99; -.
DR   BioCyc; SENT99287:STM0150-MONOMER; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004840; Amoino_acid_permease_CS.
DR   Pfam; PF00324; AA_permease; 1.
DR   PIRSF; PIRSF006060; AA_transporter; 1.
DR   PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0CK99.
DR   SWISS-2DPAGE; P0CK99.
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..457
FT                   /note="Aromatic amino acid transport protein AroP"
FT                   /id="PRO_0000054197"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..117
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..155
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        177..201
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..271
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..333
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        355..358
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        380..400
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        422..425
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        447..457
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   457 AA;  49874 MW;  CAF14EF9EB2624F9 CRC64;
     MMDSQQHGEQ LKRGLKNRHI QLIALGGAIG TGLFLGSASV IQSAGPGIIL GYAIAGFIAF
     LIMRQLGEMV VEEPVAGSFS HFAYKYWGGF AGFASGWNYW VLYVLVAMAE LTAVGKYIQF
     WYPEIPTWAS AAAFFVIINA INLTNVKVFG EMEFWFAIIK VIAVIAMILF GAWLLFSDTA
     GPQATVRNLW EQGGFLPHGW TGLVMMMAII MFSFGGLELV GITAAEADNP EQSIPKATNQ
     VIYRILIFYI GSLAVLLSLL PWTRVTADTS PFVLIFHELG DTFVANALNI VVLTAALSVY
     NSCVYCNSRM LFGLAQQGNA PKALLNVDKR GVPVSSILVS AVVTALCVLL NYLAPESAFG
     LLMALVVSAL VINWAMISLA HMMFRRAKQQ QGVKTRFPAL FYPFGNVLCL LFMAAVLIIM
     LMTPGMAISV WLIPVWLLIL GVGYLCKEKT AKTVKAH
//

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