(data stored in ACNUC7421 zone)

SWISSPROT: DKSA_SALTY

ID   DKSA_SALTY              Reviewed;         151 AA.
AC   P0A1G5; Q9ZIW3;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   11-DEC-2019, entry version 80.
DE   RecName: Full=RNA polymerase-binding transcription factor DksA {ECO:0000255|HAMAP-Rule:MF_00926};
GN   Name=dksA {ECO:0000255|HAMAP-Rule:MF_00926}; OrderedLocusNames=STM0186;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=F98;
RX   PubMed=9573095;
RA   Turner A.K., Lovell M.A., Hulme S.D., Zhang-Barber L., Barrow P.A.;
RT   "Identification of Salmonella typhimurium genes required for colonization
RT   of the chicken alimentary tract and for virulence in newly hatched
RT   chicks.";
RL   Infect. Immun. 66:2099-2106(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Transcription factor that acts by binding directly to the RNA
CC       polymerase (RNAP). Required for negative regulation of rRNA expression
CC       and positive regulation of several amino acid biosynthesis promoters.
CC       Also required for regulation of fis expression. {ECO:0000255|HAMAP-
CC       Rule:MF_00926}.
CC   -!- SUBUNIT: Interacts directly with the RNA polymerase.
CC       {ECO:0000255|HAMAP-Rule:MF_00926}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00926}.
CC   -!- SIMILARITY: Belongs to the DksA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00926}.
DR   EMBL; AF010249; AAD01437.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL19150.1; -; Genomic_DNA.
DR   RefSeq; NP_459191.1; NC_003197.2.
DR   RefSeq; WP_001155232.1; NC_003197.2.
DR   SMR; P0A1G5; -.
DR   PaxDb; P0A1G5; -.
DR   PRIDE; P0A1G5; -.
DR   EnsemblBacteria; AAL19150; AAL19150; STM0186.
DR   GeneID; 1251704; -.
DR   GeneID; 34152657; -.
DR   KEGG; stm:STM0186; -.
DR   PATRIC; fig|99287.12.peg.196; -.
DR   eggNOG; ENOG4108V7X; Bacteria.
DR   eggNOG; COG1734; LUCA.
DR   HOGENOM; HOG000178407; -.
DR   KO; K06204; -.
DR   OMA; AQERHEK; -.
DR   PhylomeDB; P0A1G5; -.
DR   BioCyc; SENT99287:STM0186-MONOMER; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00926; DksA; 1.
DR   InterPro; IPR012784; DksA_RNA_pol-bd.
DR   InterPro; IPR037187; DnaK_N.
DR   InterPro; IPR020460; Znf_C4-type_bac.
DR   InterPro; IPR000962; Znf_DskA_TraR.
DR   InterPro; IPR020458; Znf_DskA_TraR_CS.
DR   Pfam; PF01258; zf-dskA_traR; 1.
DR   PRINTS; PR00618; DKSAZNFINGER.
DR   SUPFAM; SSF109635; SSF109635; 1.
DR   TIGRFAMs; TIGR02420; dksA; 1.
DR   PROSITE; PS01102; ZF_DKSA_1; 1.
DR   PROSITE; PS51128; ZF_DKSA_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0A1G5.
DR   SWISS-2DPAGE; P0A1G5.
KW   Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..151
FT                   /note="RNA polymerase-binding transcription factor DksA"
FT                   /id="PRO_0000187540"
FT   ZN_FING         114..138
FT                   /note="dksA C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00926"
FT   COILED          34..54
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00926"
FT   METAL           114
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00926"
FT   METAL           117
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00926"
FT   METAL           135
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00926"
FT   METAL           138
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00926"
SQ   SEQUENCE   151 AA;  17516 MW;  69680BE06BD88867 CRC64;
     MQEGQNRKTS SLSILAIAGV EPYQEKPGEE YMNEAQLSHF KRILEAWRNQ LRDEVDRTVT
     HMQDEAANFP DPVDRAAQEE EFSLELRNRD RERKLIKKIE KTLKKVEDED FGYCESCGVE
     IGIRRLEARP TADLCIDCKT LAEIREKQMA G
//

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