(data stored in ACNUC7421 zone)

SWISSPROT: CRL_SALTY

ID   CRL_SALTY               Reviewed;         133 AA.
AC   Q7CR52;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 77.
DE   RecName: Full=Sigma factor-binding protein Crl;
GN   Name=crl; OrderedLocusNames=STM0319;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   PubMed=16707690; DOI=10.1128/jb.00033-06;
RA   Robbe-Saule V., Jaumouille V., Prevost M.-C., Guadagnini S., Talhouarne C.,
RA   Mathout H., Kolb A., Norel F.;
RT   "Crl activates transcription initiation of RpoS-regulated genes involved in
RT   the multicellular behavior of Salmonella enterica serovar Typhimurium.";
RL   J. Bacteriol. 188:3983-3994(2006).
CC   -!- FUNCTION: Binds to the sigma-S subunit of RNA polymerase, activating
CC       expression of sigma-S-regulated genes, such as the csgBAC operon
CC       encoding the subunits of curli proteins, and BcsA, involved in
CC       cellulose biosynthesis. {ECO:0000269|PubMed:16707690}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: Induced at late exponential and stationary phases, and at
CC       low temperatures. {ECO:0000269|PubMed:16707690}.
CC   -!- SIMILARITY: Belongs to the Crl family. {ECO:0000305}.
DR   EMBL; AE006468; AAL19275.1; -; Genomic_DNA.
DR   RefSeq; NP_459316.1; NC_003197.2.
DR   RefSeq; WP_000174696.1; NC_003197.2.
DR   PDB; 2MZ8; NMR; -; A=1-133.
DR   PDBsum; 2MZ8; -.
DR   SMR; Q7CR52; -.
DR   PaxDb; Q7CR52; -.
DR   PRIDE; Q7CR52; -.
DR   EnsemblBacteria; AAL19275; AAL19275; STM0319.
DR   GeneID; 1251838; -.
DR   KEGG; stm:STM0319; -.
DR   PATRIC; fig|99287.12.peg.339; -.
DR   eggNOG; ENOG4108UVK; Bacteria.
DR   eggNOG; ENOG4111IQF; LUCA.
DR   HOGENOM; HOG000282284; -.
DR   KO; K11926; -.
DR   OMA; FWGWWLE; -.
DR   BioCyc; SENT99287:STM0319-MONOMER; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.310.230; -; 1.
DR   HAMAP; MF_01178; Crl; 1.
DR   InterPro; IPR009986; Tscrpt_reg_Crl.
DR   InterPro; IPR038208; Tscrpt_reg_Crl_sf.
DR   Pfam; PF07417; Crl; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q7CR52.
DR   SWISS-2DPAGE; Q7CR52.
KW   3D-structure; Activator; Coiled coil; Cytoplasm; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..133
FT                   /note="Sigma factor-binding protein Crl"
FT                   /id="PRO_0000268904"
FT   REGION          99..122
FT                   /note="Essential for activity"
FT                   /evidence="ECO:0000250"
FT   COILED          90..111
FT                   /evidence="ECO:0000255"
FT   HELIX           9..16
FT                   /evidence="ECO:0000244|PDB:2MZ8"
FT   HELIX           17..19
FT                   /evidence="ECO:0000244|PDB:2MZ8"
FT   STRAND          33..35
FT                   /evidence="ECO:0000244|PDB:2MZ8"
FT   STRAND          44..46
FT                   /evidence="ECO:0000244|PDB:2MZ8"
FT   STRAND          58..62
FT                   /evidence="ECO:0000244|PDB:2MZ8"
FT   STRAND          64..68
FT                   /evidence="ECO:0000244|PDB:2MZ8"
FT   HELIX           90..114
FT                   /evidence="ECO:0000244|PDB:2MZ8"
FT   STRAND          117..119
FT                   /evidence="ECO:0000244|PDB:2MZ8"
SQ   SEQUENCE   133 AA;  15797 MW;  0619C3D79FFF7897 CRC64;
     MTLPSGHPKS RLIKKFTALG PYIREGQCED NRFFFDCLAV CVNVKPAPEK REFWGWWMEL
     EAQEKRFTYR YQFGLFDKEG NWTVVPINET EVVERLEYTL REFHEKLRDL LISMELALEP
     SDDFNDEPVK LSA
//

If you have problems or comments...

PBIL Back to PBIL home page