(data stored in ACNUC7421 zone)

SWISSPROT: QUEC_SALTY

ID   QUEC_SALTY              Reviewed;         231 AA.
AC   Q7CR22;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 93.
DE   RecName: Full=7-cyano-7-deazaguanine synthase {ECO:0000255|HAMAP-Rule:MF_01633};
DE            EC=6.3.4.20 {ECO:0000255|HAMAP-Rule:MF_01633};
DE   AltName: Full=7-cyano-7-carbaguanine synthase {ECO:0000255|HAMAP-Rule:MF_01633};
DE   AltName: Full=PreQ(0) synthase {ECO:0000255|HAMAP-Rule:MF_01633};
DE   AltName: Full=Queuosine biosynthesis protein QueC {ECO:0000255|HAMAP-Rule:MF_01633};
GN   Name=queC {ECO:0000255|HAMAP-Rule:MF_01633}; OrderedLocusNames=STM0455;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Catalyzes the ATP-dependent conversion of 7-carboxy-7-
CC       deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
CC       {ECO:0000255|HAMAP-Rule:MF_01633}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-
CC         deazaguanine + ADP + H(+) + H2O + phosphate; Xref=Rhea:RHEA:27982,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:45075,
CC         ChEBI:CHEBI:61036, ChEBI:CHEBI:456216; EC=6.3.4.20;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01633};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01633};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01633};
CC   -!- PATHWAY: Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01633}.
CC   -!- SIMILARITY: Belongs to the QueC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01633}.
DR   EMBL; AE006468; AAL19410.1; -; Genomic_DNA.
DR   RefSeq; NP_459451.1; NC_003197.2.
DR   RefSeq; WP_000817201.1; NC_003197.2.
DR   SMR; Q7CR22; -.
DR   PaxDb; Q7CR22; -.
DR   PRIDE; Q7CR22; -.
DR   EnsemblBacteria; AAL19410; AAL19410; STM0455.
DR   GeneID; 1251975; -.
DR   KEGG; stm:STM0455; -.
DR   PATRIC; fig|99287.12.peg.487; -.
DR   eggNOG; ENOG4105FD2; Bacteria.
DR   eggNOG; COG0603; LUCA.
DR   HOGENOM; HOG000110563; -.
DR   KO; K06920; -.
DR   OMA; VWVPARN; -.
DR   PhylomeDB; Q7CR22; -.
DR   BioCyc; SENT99287:STM0455-MONOMER; -.
DR   UniPathway; UPA00391; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016879; F:ligase activity, forming carbon-nitrogen bonds; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008616; P:queuosine biosynthetic process; IBA:GO_Central.
DR   CDD; cd01995; ExsB; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_01633; QueC; 1.
DR   InterPro; IPR018317; QueC.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR42914; PTHR42914; 1.
DR   Pfam; PF06508; QueC; 1.
DR   PIRSF; PIRSF006293; ExsB; 1.
DR   TIGRFAMs; TIGR00364; TIGR00364; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q7CR22.
DR   SWISS-2DPAGE; Q7CR22.
KW   ATP-binding; Ligase; Metal-binding; Nucleotide-binding;
KW   Queuosine biosynthesis; Reference proteome; Zinc.
FT   CHAIN           1..231
FT                   /note="7-cyano-7-deazaguanine synthase"
FT                   /id="PRO_0000246920"
FT   NP_BIND         8..18
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01633"
FT   METAL           188
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01633"
FT   METAL           197
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01633"
FT   METAL           200
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01633"
FT   METAL           203
FT                   /note="Zinc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01633"
SQ   SEQUENCE   231 AA;  25455 MW;  EA2CBE33850627F8 CRC64;
     MKRAVVVFSG GQDSTTCLAQ ARHQYDEVHC VTFDYGQRHR AEIDVARALA LKLGARAHKV
     LDVTLLNELA VSSLTRDSIP VPDYEPNADG IPNTFVPGRN ILFLTLAAIY AYQVKAEAVI
     TGVCETDFSG YPDCRDEFVK ALNHAVNLGM AKDIRFETPL MWIDKAETWA LADYWGQLDL
     VREETLTCYN GIKGDGCGHC AACNLRANGL NHYLSNKAAV MAAMKQKTGL R
//

If you have problems or comments...

PBIL Back to PBIL home page