(data stored in ACNUC4305 zone)

SWISSPROT: T4S4_HUMAN

ID   T4S4_HUMAN              Reviewed;         202 AA.
AC   P48230; B2RDA4;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   11-DEC-2019, entry version 145.
DE   RecName: Full=Transmembrane 4 L6 family member 4;
DE   AltName: Full=Intestine and liver tetraspan membrane protein;
DE            Short=IL-TMP;
GN   Name=TM4SF4; Synonyms=ILTMP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Intestine, and Liver;
RX   PubMed=7665614; DOI=10.1074/jbc.270.37.21907;
RA   Wice B.M., Gordon J.I.;
RT   "A tetraspan membrane glycoprotein produced in the human intestinal
RT   epithelium and liver that can regulate cell density-dependent
RT   proliferation.";
RL   J. Biol. Chem. 270:21907-21918(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124.
RC   TISSUE=Liver;
RX   PubMed=19159218; DOI=10.1021/pr8008012;
RA   Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT   "Glycoproteomics analysis of human liver tissue by combination of multiple
RT   enzyme digestion and hydrazide chemistry.";
RL   J. Proteome Res. 8:651-661(2009).
CC   -!- FUNCTION: Regulates the adhesive and proliferative status of intestinal
CC       epithelial cells. Can mediate density-dependent cell proliferation.
CC   -!- INTERACTION:
CC       Q969F0:FATE1; NbExp=3; IntAct=EBI-8650934, EBI-743099;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Jejunum and liver.
CC   -!- PTM: N-glycosylated. Glycosylation is required for the growth
CC       inhibitory effect. {ECO:0000269|PubMed:19159218}.
CC   -!- SIMILARITY: Belongs to the L6 tetraspanin family. {ECO:0000305}.
DR   EMBL; U31449; AAA74745.1; -; mRNA.
DR   EMBL; BT007430; AAP36098.1; -; mRNA.
DR   EMBL; AK315464; BAG37851.1; -; mRNA.
DR   EMBL; CH471052; EAW78871.1; -; Genomic_DNA.
DR   EMBL; BC001386; AAH01386.1; -; mRNA.
DR   CCDS; CCDS46932.1; -.
DR   RefSeq; NP_004608.1; NM_004617.3.
DR   BioGrid; 112959; 3.
DR   IntAct; P48230; 21.
DR   MINT; P48230; -.
DR   STRING; 9606.ENSP00000305852; -.
DR   TCDB; 8.A.75.1.1; the transmembrane 4 superfamily 4 (tm4sf4) family.
DR   iPTMnet; P48230; -.
DR   BioMuta; TM4SF4; -.
DR   DMDM; 1352457; -.
DR   MassIVE; P48230; -.
DR   PaxDb; P48230; -.
DR   PeptideAtlas; P48230; -.
DR   PRIDE; P48230; -.
DR   ProteomicsDB; 55873; -.
DR   DNASU; 7104; -.
DR   Ensembl; ENST00000305354; ENSP00000305852; ENSG00000169903.
DR   GeneID; 7104; -.
DR   KEGG; hsa:7104; -.
DR   UCSC; uc003exd.3; human.
DR   CTD; 7104; -.
DR   DisGeNET; 7104; -.
DR   EuPathDB; HostDB:ENSG00000169903.6; -.
DR   GeneCards; TM4SF4; -.
DR   HGNC; HGNC:11856; TM4SF4.
DR   HPA; HPA046430; -.
DR   MIM; 606567; gene.
DR   neXtProt; NX_P48230; -.
DR   OpenTargets; ENSG00000169903; -.
DR   PharmGKB; PA36557; -.
DR   eggNOG; ENOG410IKWR; Eukaryota.
DR   eggNOG; ENOG4111RYW; LUCA.
DR   GeneTree; ENSGT00950000182770; -.
DR   HOGENOM; HOG000030899; -.
DR   InParanoid; P48230; -.
DR   OMA; VIDNNDH; -.
DR   OrthoDB; 922490at2759; -.
DR   PhylomeDB; P48230; -.
DR   TreeFam; TF331371; -.
DR   ChiTaRS; TM4SF4; human.
DR   GenomeRNAi; 7104; -.
DR   Pharos; P48230; Tbio.
DR   PRO; PR:P48230; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; P48230; protein.
DR   Bgee; ENSG00000169903; Expressed in 76 organ(s), highest expression level in duodenum.
DR   ExpressionAtlas; P48230; baseline and differential.
DR   Genevisible; P48230; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042246; P:tissue regeneration; IEA:Ensembl.
DR   InterPro; IPR008661; L6_membrane.
DR   PANTHER; PTHR14198; PTHR14198; 1.
DR   Pfam; PF05805; L6_membrane; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P48230.
DR   SWISS-2DPAGE; P48230.
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..202
FT                   /note="Transmembrane 4 L6 family member 4"
FT                   /id="PRO_0000219299"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..45
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..93
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..158
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..202
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        124
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:19159218"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   202 AA;  21396 MW;  402742A2F5F8598F CRC64;
     MCTGGCARCL GGTLIPLAFF GFLANILLFF PGGKVIDDND HLSQEIWFFG GILGSGVLMI
     FPALVFLGLK NNDCCGCCGN EGCGKRFAMF TSTIFAVVGF LGAGYSFIIS AISINKGPKC
     LMANSTWGYP FHDGDYLNDE ALWNKCREPL NVVPWNLTLF SILLVVGGIQ MVLCAIQVVN
     GLLGTLCGDC QCCGCCGGDG PV
//

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