(data stored in ACNUC7421 zone)

SWISSPROT: Q75CW8_ASHGO

ID   Q75CW8_ASHGO            Unreviewed;       450 AA.
AC   Q75CW8;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 91.
DE   RecName: Full=Mannan endo-1,6-alpha-mannosidase {ECO:0000256|PIRNR:PIRNR016302};
DE            EC=3.2.1.101 {ECO:0000256|PIRNR:PIRNR016302};
GN   ORFNames=AGOS_ACL202W {ECO:0000313|EMBL:AAS51026.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51026.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51026.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->6)-alpha-D-mannosidic linkages in
CC         unbranched (1->6)-mannans.; EC=3.2.1.101;
CC         Evidence={ECO:0000256|PIRNR:PIRNR016302};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 76 family.
CC       {ECO:0000256|PIRNR:PIRNR016302}.
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DR   EMBL; AE016816; AAS51026.1; -; Genomic_DNA.
DR   RefSeq; NP_983202.1; NM_208555.1.
DR   CAZy; GH76; Glycoside Hydrolase Family 76.
DR   EnsemblFungi; AAS51026; AAS51026; AGOS_ACL202W.
DR   GeneID; 4619313; -.
DR   KEGG; ago:AGOS_ACL202W; -.
DR   HOGENOM; HOG000178818; -.
DR   InParanoid; Q75CW8; -.
DR   OMA; CERNGLC; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0008496; F:mannan endo-1,6-alpha-mannosidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007117; P:budding cell bud growth; IBA:GO_Central.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR   GO; GO:0009272; P:fungal-type cell wall biogenesis; IBA:GO_Central.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR005198; Glyco_hydro_76.
DR   InterPro; IPR014480; Mannan-1_6-alpha_mannosidase.
DR   PANTHER; PTHR12145; PTHR12145; 1.
DR   Pfam; PF03663; Glyco_hydro_76; 1.
DR   PIRSF; PIRSF016302; Man_a_manosd; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q75CW8.
DR   SWISS-2DPAGE; Q75CW8.
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR016302};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR016302};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   REGION          387..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   450 AA;  50504 MW;  33CC96ABBAD083F6 CRC64;
     MYALVIFNIV LCNALDVNFN SSASICNATK LIQQGILDYY EGLRPGGRVG FFQEPYYWWM
     AGDVFGGMVE NWYLCDNTEY KDLLTEAMVS QIGENKDYVP WHQRMVEGND DQGIWGLLVM
     DAAERDFPDA PPDQAPGWLA LAQAVFNTMW ARWDMDNCAG GLLWQIYPWN VGYDYKNTIS
     NGYLFQIAAR LARFTGNSTY GRVAETVFDW LVDSKLVQLD NVALVLDGAH VYTNCTDFTR
     YEWTYNYGVV LGGCAYMYNF TNGSPVWANR LNRVLNGALL FFENGIMYER TCQDVDRCNN
     DQRFFKSIFT RMLALTSVLA PHTKARIEPN IRKSAEAAAK SCNGGSDGHT CGLVWRNYTW
     DGKAGLGEQL CALEIIQNTL IHTKRPPLTA KQGAKSKGDP AAGLNSSRYD LPIVHPPSGQ
     KSSILTTLRS LSSSAKVHRH YASTSTRVVQ
//

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