(data stored in ACNUC7421 zone)

SWISSPROT: Q75CW7_ASHGO

ID   Q75CW7_ASHGO            Unreviewed;       448 AA.
AC   Q75CW7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 92.
DE   RecName: Full=Mannan endo-1,6-alpha-mannosidase {ECO:0000256|PIRNR:PIRNR016302};
DE            EC=3.2.1.101 {ECO:0000256|PIRNR:PIRNR016302};
GN   ORFNames=AGOS_ACL201W {ECO:0000313|EMBL:AAS51027.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51027.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51027.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->6)-alpha-D-mannosidic linkages in
CC         unbranched (1->6)-mannans.; EC=3.2.1.101;
CC         Evidence={ECO:0000256|PIRNR:PIRNR016302};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 76 family.
CC       {ECO:0000256|PIRNR:PIRNR016302}.
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DR   EMBL; AE016816; AAS51027.1; -; Genomic_DNA.
DR   RefSeq; NP_983203.1; NM_208556.1.
DR   CAZy; GH76; Glycoside Hydrolase Family 76.
DR   EnsemblFungi; AAS51027; AAS51027; AGOS_ACL201W.
DR   GeneID; 4619323; -.
DR   KEGG; ago:AGOS_ACL201W; -.
DR   HOGENOM; HOG000178818; -.
DR   InParanoid; Q75CW7; -.
DR   OMA; KWHEDSG; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008496; F:mannan endo-1,6-alpha-mannosidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007117; P:budding cell bud growth; IBA:GO_Central.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR   GO; GO:0009272; P:fungal-type cell wall biogenesis; IBA:GO_Central.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR005198; Glyco_hydro_76.
DR   InterPro; IPR014480; Mannan-1_6-alpha_mannosidase.
DR   PANTHER; PTHR12145; PTHR12145; 1.
DR   Pfam; PF03663; Glyco_hydro_76; 1.
DR   PIRSF; PIRSF016302; Man_a_manosd; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q75CW7.
DR   SWISS-2DPAGE; Q75CW7.
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR016302};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR016302};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..448
FT                   /note="Mannan endo-1,6-alpha-mannosidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012045384"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          385..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   448 AA;  49764 MW;  BF3DD22DF53CB922 CRC64;
     MYVLLVILNI VLSNALDVDF NSSESICDAT KLIQVGILDY YEGAKPGGRA GFLVKPYYWW
     MAGEAFGGMV ENWYLCNNTE YQDLLTDAMV SQIGENKDYM PSHQKMVEGN DDQGIWGLLV
     MGAAERNFPD APPERAPGWL ALAQAVFNTM WARWDPENCG GGLRWQIFPW NGGYDYKNTI
     SNACLFQIAA RLARFTGNST YQDVAETVFD WLVDVKLVEL ENDARVLDGA HISERCEDHS
     QLEWTYNHGV VLGGCAYMYN ITNGSAVWGD RLNKVLNGSL LFFENGILYE RACQDVNKCN
     DDQRSFRSIF SRMLALTSVL APHTKARIEP NIRKSAEAAA KSCSGGRDGH TCGMVWRNYT
     WDGKYGLGEQ LSALEIIQNT LIHTKPPPTT ANEGAKSQGD PGAGLQLSSP NSITLPTRQI
     RLKDRVGAGF ATVVFLLPFI TGSIWMSI
//

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