(data stored in ACNUC7421 zone)

SWISSPROT: Q75CS3_ASHGO

ID   Q75CS3_ASHGO            Unreviewed;       319 AA.
AC   Q75CS3;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 89.
DE   SubName: Full=ACL154Wp {ECO:0000313|EMBL:AAS51074.1};
GN   ORFNames=AGOS_ACL154W {ECO:0000313|EMBL:AAS51074.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51074.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51074.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
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DR   EMBL; AE016816; AAS51074.1; -; Genomic_DNA.
DR   RefSeq; NP_983250.1; NM_208603.2.
DR   STRING; 33169.AAS51074; -.
DR   EnsemblFungi; AAS51074; AAS51074; AGOS_ACL154W.
DR   GeneID; 4619370; -.
DR   KEGG; ago:AGOS_ACL154W; -.
DR   HOGENOM; HOG000246524; -.
DR   InParanoid; Q75CS3; -.
DR   OMA; TICPPGC; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005640; C:nuclear outer membrane; IEA:EnsemblFungi.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0004392; F:heme oxygenase (decyclizing) activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:EnsemblFungi.
DR   GO; GO:0042167; P:heme catabolic process; IBA:GO_Central.
DR   GO; GO:0006788; P:heme oxidation; IBA:GO_Central.
DR   GO; GO:0055072; P:iron ion homeostasis; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR   Gene3D; 1.20.910.10; -; 1.
DR   InterPro; IPR002051; Haem_Oase.
DR   InterPro; IPR016053; Haem_Oase-like.
DR   InterPro; IPR016084; Haem_Oase-like_multi-hlx.
DR   PANTHER; PTHR10720; PTHR10720; 1.
DR   Pfam; PF01126; Heme_oxygenase; 1.
DR   PIRSF; PIRSF000343; Haem_Oase; 1.
DR   SUPFAM; SSF48613; SSF48613; 1.
PE   4: Predicted;
DR   PRODOM; Q75CS3.
DR   SWISS-2DPAGE; Q75CS3.
KW   Iron {ECO:0000256|PIRSR:PIRSR000343-2}; Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000343-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   METAL           39
FT                   /note="Iron (heme axial ligand)"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000343-2"
SQ   SEQUENCE   319 AA;  35434 MW;  C9ECEF99A4BAE021 CRC64;
     MATKSENTPI YTQASPVVPL PTDTGALANR INFHTRELHS KADAFVSAKF AVALRHPSIY
     RQGLLAMYYI FRSVEQHIDR LLRAPATADE ARIGEILRAF WRPEFARAPA LVQDFEVYYA
     AEYSTSAQLH QFLDSYELPP RLAAAVADIE AAALRQPWTI LAHCHVLYLA LFAGGRVMRS
     ALSRQLGLLP RAAGLSARET QLRGTHFFTF GAGAGEENKA RVAYKRAYEL ATRTALSEAE
     KADVIDAARA DFDHIQAVMA ELAVRNRQEL LGSPSYRLLT FLGEEWRYRT KNSPQLLALA
     AVLSALFLYA AARVLVARA
//

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