(data stored in ACNUC7421 zone)

SWISSPROT: Q75BZ5_ASHGO

ID   Q75BZ5_ASHGO            Unreviewed;       211 AA.
AC   Q75BZ5;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 92.
DE   SubName: Full=ACR124Wp {ECO:0000313|EMBL:AAS51350.1};
GN   ORFNames=AGOS_ACR124W {ECO:0000313|EMBL:AAS51350.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51350.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51350.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC       {ECO:0000256|RuleBase:RU004474}.
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DR   EMBL; AE016816; AAS51350.1; -; Genomic_DNA.
DR   RefSeq; NP_983526.1; NM_208879.1.
DR   STRING; 33169.AAS51350; -.
DR   EnsemblFungi; AAS51350; AAS51350; AGOS_ACR124W.
DR   GeneID; 4619658; -.
DR   KEGG; ago:AGOS_ACR124W; -.
DR   HOGENOM; HOG000040235; -.
DR   InParanoid; Q75BZ5; -.
DR   KO; K00287; -.
DR   OMA; KEMKYFR; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IBA:GO_Central.
DR   GO; GO:0050661; F:NADP binding; IBA:GO_Central.
DR   GO; GO:0046452; P:dihydrofolate metabolic process; IBA:GO_Central.
DR   GO; GO:0046655; P:folic acid metabolic process; IBA:GO_Central.
DR   GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IBA:GO_Central.
DR   CDD; cd00209; DHFR; 1.
DR   Gene3D; 3.40.430.10; -; 1.
DR   InterPro; IPR012259; DHFR.
DR   InterPro; IPR024072; DHFR-like_dom_sf.
DR   InterPro; IPR017925; DHFR_CS.
DR   InterPro; IPR001796; DHFR_dom.
DR   PANTHER; PTHR22778:SF16; PTHR22778:SF16; 1.
DR   Pfam; PF00186; DHFR_1; 1.
DR   SUPFAM; SSF53597; SSF53597; 1.
DR   PROSITE; PS00075; DHFR_1; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q75BZ5.
DR   SWISS-2DPAGE; Q75BZ5.
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   DOMAIN          7..207
FT                   /note="DHFR"
FT                   /evidence="ECO:0000259|PROSITE:PS51330"
SQ   SEQUENCE   211 AA;  23672 MW;  AC03ABF4D756B3FF CRC64;
     MGISRVPVVS IVACLLPEYG IGYQGQLPWR LAREMKYFRQ ATTATFDPTK RNAVVMGRKT
     WESIPARWRP LPGRLNVVVS RTYTSPWAHD ENGHVITSNS LQQCVRQLQE QARALGVERI
     YIMGGAEIYN QSYDLCDHLL VTELQVAPDG PAVLLDTFLA RDVLEQSFAK NSAGPRALLP
     PSVELPECPA TALEEGGFQF RFALYDHLNR D
//

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