(data stored in ACNUC7421 zone)

SWISSPROT: Q75BW3_ASHGO

ID   Q75BW3_ASHGO            Unreviewed;       800 AA.
AC   Q75BW3;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 2.
DT   11-DEC-2019, entry version 116.
DE   SubName: Full=ACR158Wp {ECO:0000313|EMBL:AAS51384.2};
GN   ORFNames=AGOS_ACR158W {ECO:0000313|EMBL:AAS51384.2};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51384.2, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51384.2, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|SAAS:SAAS01128831};
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DR   EMBL; AE016816; AAS51384.2; -; Genomic_DNA.
DR   RefSeq; NP_983560.2; NM_208913.2.
DR   STRING; 33169.AAS51384; -.
DR   EnsemblFungi; AAS51384; AAS51384; AGOS_ACR158W.
DR   GeneID; 4619692; -.
DR   KEGG; ago:AGOS_ACR158W; -.
DR   HOGENOM; HOG000115780; -.
DR   InParanoid; Q75BW3; -.
DR   KO; K19806; -.
DR   OMA; MVQNLTQ; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR   Gene3D; 3.40.250.10; -; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   SUPFAM; SSF52821; SSF52821; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   4: Predicted;
DR   PRODOM; Q75BW3.
DR   SWISS-2DPAGE; Q75BW3.
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00160,
KW   ECO:0000256|SAAS:SAAS01031440};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01031415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   DOMAIN          447..787
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          701..778
FT                   /note="TYR_PHOSPHATASE_2"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   ACT_SITE        716
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00160"
SQ   SEQUENCE   800 AA;  89879 MW;  8633FA7564C9FAC8 CRC64;
     MAGLDVRNIY NLKEVVGPAR AQQCRTVQPA ASPTFGALRL SGSPAAQPLS PTSRTMAQRA
     EVGEAEHLLR ERTQVLTAAE WRERQAQLGD ALVLDLSTQG FQLKGAQRRV HLSFPSTLLR
     RPNFPFSKLV RTLNSETQAS LLEHLDTSNA IVLFDDGSSF WNNCLQTTIT VLRKLLTYLE
     EQKAHTQRQV PIFLLQGGVK AFESHHFVSP AVKNGSSADK PKLTLKLCIP GRTQDSGSDG
     TGVTGRSALD NSSELFIQSM KGDTLHYSPS SLLKYFKYHT PAKLPKHVPP WLSPFNRACD
     SVLSQIMGKF ELLEKLEVMR LQQCLSGSTP SSTYSQLAKT SSKLYSLRDL QKKYRSPRVN
     LEDGDEARAF HSKIDDSYNT LGQCKLERDI HEELNDNENK EILNKLAFGH SSSDAIEAAS
     VVRQEDEDHS DAPNEYVITQ GLNSFTKNRY SNIIPYEHTR VRLEPSPVGN RSLAKTFLQS
     TSHLSPAAAP SDSNPVVDHL KVPAPSSYFV KNTESAFTPL AGTTPNEPFN DYFNANYLTL
     PEINSKCRYI ATQAPLPSTV DDFWKVITTN SVKVIISLNS DDELNLRKWD IYWGSDSVHK
     FNITILHSFE NVRGLDGNIV RVFKVQKKST VAGSSAEDSQ SNTHIVYQIQ YKKWLDSCGI
     VMSDFLQLYN VKNALLNDPD SFIRQQLEDR NTLIDIDEDP SLFRRTESHS PLLVHCSAGC
     GRTGVFITLD FLLTVLHSPL QVYNKIDVWN MEEDLVFIVV NEFRKQRISM VQNLTQYITC
     YESLLDFFSL HENRGAVAQY
//

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