(data stored in ACNUC7421 zone)

SWISSPROT: Q75BP5_ASHGO

ID   Q75BP5_ASHGO            Unreviewed;       381 AA.
AC   Q75BP5;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 121.
DE   RecName: Full=DNA repair protein RAD51 homolog {ECO:0000256|RuleBase:RU364139};
GN   ORFNames=AGOS_ACR226W {ECO:0000313|EMBL:AAS51452.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51452.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51452.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required both for recombination and for the repair of DNA
CC       damage caused by X-rays. {ECO:0000256|RuleBase:RU364139}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364139}.
CC   -!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily.
CC       {ECO:0000256|RuleBase:RU364139}.
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DR   EMBL; AE016816; AAS51452.1; -; Genomic_DNA.
DR   RefSeq; NP_983628.1; NM_208981.1.
DR   STRING; 33169.AAS51452; -.
DR   EnsemblFungi; AAS51452; AAS51452; AGOS_ACR226W.
DR   GeneID; 4619760; -.
DR   KEGG; ago:AGOS_ACR226W; -.
DR   HOGENOM; HOG000227426; -.
DR   InParanoid; Q75BP5; -.
DR   KO; K04482; -.
DR   OMA; YNTDHQT; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0000794; C:condensed nuclear chromosome; IBA:GO_Central.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008094; F:DNA-dependent ATPase activity; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0000150; F:recombinase activity; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0070192; P:chromosome organization involved in meiotic cell cycle; IBA:GO_Central.
DR   GO; GO:0000730; P:DNA recombinase assembly; IBA:GO_Central.
DR   GO; GO:0030491; P:heteroduplex formation; IEA:EnsemblFungi.
DR   GO; GO:0000709; P:meiotic joint molecule formation; IEA:EnsemblFungi.
DR   GO; GO:0043504; P:mitochondrial DNA repair; IEA:EnsemblFungi.
DR   GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR   GO; GO:1990426; P:mitotic recombination-dependent replication fork processing; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:EnsemblFungi.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR   GO; GO:0042148; P:strand invasion; IBA:GO_Central.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IEA:EnsemblFungi.
DR   CDD; cd01123; Rad51_DMC1_radA; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011941; DNA_recomb/repair_Rad51.
DR   InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR   InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR   InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR033925; Rad51_DMC1_RadA.
DR   InterPro; IPR020588; RecA_ATP-bd.
DR   InterPro; IPR020587; RecA_monomer-monomer_interface.
DR   Pfam; PF08423; Rad51; 1.
DR   PIRSF; PIRSF005856; Rad51; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF47794; SSF47794; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02239; recomb_RAD51; 1.
DR   PROSITE; PS50162; RECA_2; 1.
DR   PROSITE; PS50163; RECA_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q75BP5.
DR   SWISS-2DPAGE; Q75BP5.
KW   ATP-binding {ECO:0000256|RuleBase:RU003422};
KW   DNA damage {ECO:0000256|RuleBase:RU364139};
KW   DNA recombination {ECO:0000256|RuleBase:RU364139};
KW   DNA repair {ECO:0000256|RuleBase:RU364139};
KW   DNA-binding {ECO:0000256|RuleBase:RU364139};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU003422};
KW   Nucleus {ECO:0000256|RuleBase:RU364139};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   DOMAIN          136..307
FT                   /note="RECA_2"
FT                   /evidence="ECO:0000259|PROSITE:PS50162"
FT   DOMAIN          314..377
FT                   /note="RECA_3"
FT                   /evidence="ECO:0000259|PROSITE:PS50163"
SQ   SEQUENCE   381 AA;  41483 MW;  DC452545ADC9833D CRC64;
     MSQVQEHIIQ DPHSSQYNIH ATGASERQGS SEHTDGDVIE VHAESGRGQG YEEDVALAAF
     VPLERLQVNG ITNNDLKKLR ENGLHTVEAV AYAPRKDLLE IKGISEAKAD KLLAEAARLV
     PMGFVTAADF HLRRAEMICL TTGSKNLDTL LGGGIETGSI TELFGEFRTG KSQLCHTLAV
     TCQIPLDMGG GEGKCLYIDT EGTFRPIRLV SIAQRFGLDP DDALNNVAYA RAYNADHQLR
     LLDAAAQMMS ESRFSLIVVD SIMALYRTDF SGRGELSARQ MHLAKFMRAL QRLADQFGVA
     VVVTNQVVAQ VDGAAMFNPD PKKPIGGNIM AHSSTTRLGF KKGKGCQRLC KVVDSPCLPE
     AECVFAIYED GIGDPREDDE D
//

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