(data stored in ACNUC7421 zone)

SWISSPROT: Q758Q4_ASHGO

ID   Q758Q4_ASHGO            Unreviewed;       957 AA.
AC   Q758Q4;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 2.
DT   11-DEC-2019, entry version 129.
DE   RecName: Full=Calcium-transporting ATPase {ECO:0000256|RuleBase:RU361146};
DE            EC=7.2.2.10 {ECO:0000256|RuleBase:RU361146};
GN   ORFNames=AGOS_AEL301W {ECO:0000313|EMBL:AAS52383.2};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS52383.2, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS52383.2, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of
CC       ATP coupled with the transport of calcium.
CC       {ECO:0000256|RuleBase:RU361146}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate;
CC         Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:456216; EC=7.2.2.10;
CC         Evidence={ECO:0000256|RuleBase:RU361146};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361146}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU361146}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. {ECO:0000256|RuleBase:RU361146, ECO:0000256|SAAS:SAAS00832166}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU361146}.
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DR   EMBL; AE016818; AAS52383.2; -; Genomic_DNA.
DR   RefSeq; NP_984559.2; NM_209912.2.
DR   STRING; 33169.AAS52383; -.
DR   EnsemblFungi; AAS52383; AAS52383; AGOS_AEL301W.
DR   GeneID; 4620734; -.
DR   KEGG; ago:AGOS_AEL301W; -.
DR   HOGENOM; HOG000265621; -.
DR   InParanoid; Q758Q4; -.
DR   KO; K01537; -.
DR   OMA; VGMSDPP; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:EnsemblFungi.
DR   GO; GO:0005388; F:calcium transmembrane transporter activity, phosphorylative mechanism; IBA:GO_Central.
DR   GO; GO:0015410; F:manganese transmembrane transporter activity, phosphorylative mechanism; IBA:GO_Central.
DR   GO; GO:0008553; F:proton-exporting ATPase activity, phosphorylative mechanism; IBA:GO_Central.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0030026; P:cellular manganese ion homeostasis; IEA:EnsemblFungi.
DR   GO; GO:0016236; P:macroautophagy; IEA:EnsemblFungi.
DR   Gene3D; 3.40.1110.10; -; 1.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR   InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006413; P-type_ATPase_IIA_PMR1.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   Pfam; PF00689; Cation_ATPase_C; 1.
DR   Pfam; PF00690; Cation_ATPase_N; 1.
DR   PRINTS; PR00120; HATPASE.
DR   SMART; SM00831; Cation_ATPase_N; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   SUPFAM; SSF81653; SSF81653; 1.
DR   SUPFAM; SSF81660; SSF81660; 1.
DR   SUPFAM; SSF81665; SSF81665; 1.
DR   TIGRFAMs; TIGR01522; ATPase-IIA2_Ca; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 2.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q758Q4.
DR   SWISS-2DPAGE; Q758Q4.
KW   ATP-binding {ECO:0000256|RuleBase:RU361146, ECO:0000256|SAAS:SAAS00832164};
KW   Calcium {ECO:0000256|RuleBase:RU361146};
KW   Calcium transport {ECO:0000256|RuleBase:RU361146};
KW   Ion transport {ECO:0000256|RuleBase:RU361146};
KW   Membrane {ECO:0000256|RuleBase:RU361146, ECO:0000256|SAAS:SAAS00832173};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU361146,
KW   ECO:0000256|SAAS:SAAS00832168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Translocase {ECO:0000256|SAAS:SAAS01237809};
KW   Transmembrane {ECO:0000256|RuleBase:RU361146,
KW   ECO:0000256|SAAS:SAAS00832175};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361146,
KW   ECO:0000256|SAAS:SAAS00832181}; Transport {ECO:0000256|RuleBase:RU361146}.
FT   TRANSMEM        98..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        123..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        296..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        326..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        818..838
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        853..870
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        890..911
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        917..935
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   DOMAIN          43..119
FT                   /note="Cation_ATPase_N"
FT                   /evidence="ECO:0000259|SMART:SM00831"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   957 AA;  104535 MW;  3214DD0DF3CD0733 CRC64;
     MGSVGKMSDN PFDSYLNRSK DDSSMETKSL ASEAFLKPNA SLEYCTMTVD ETLRQLNTDS
     AKGLCDQQQV RASEQEWGTN EVTVDGEDPV WKRFMSTFVE DPLILLLIGS AVLSFLMGNI
     DDAVSITLAV VIVVSVGFVQ EYRSEKSLEA LHKLVPASCH LIRFGAETHV LASCLVPGDL
     VYFKVGDRIP ADVRIIESTD LSLDESTLTG ETEPVHKSCT PVNSATYSDV PGGIIPIGER
     TSIAYMGTLV REGHGKGIVV ATGKHTMFGA VFEMMNSIEK PKTPLQMAMD RLGKDLSYVS
     FFLIGIIFLL GVIQGRSWLE MFQISVSLAV AAIPEGLPII VTVTLALGVL RMANRKAIVR
     RLPSVETLGS VNVICSDKTG TLTANHMTAS KIWCLGSMAN KNNVLSLEAK SSGGLPGKLP
     NLKNYLSDDV KATLRIGSIC NNASFSHEHG KYLGNPTDIA LLEVLQKFDL VDERPTTTRV
     DELTFNSKRK YMAVKVDSPA NSGKHIIYVK GAFERILERS ASFIGGAGKV EKLSDSHKSL
     INDCAKSLAS EGLRTLAFAQ LECSTNKPMN DSTIQNLTFV GLIGMKDPPR STVRPAIEEL
     LQGGVHVIMI TGDAENTAVN IARQIGIPVI NPEISVLTGD RLDQMTDDQL AGVIDHVNIF
     ARATPEHKLN IVRALQKRGD IVAMTGDGVN DAPALKLADI GVAMGHMGTD VAKEASDMVL
     TDDDFSTILT AIEEGKGIFN NIQSFLTFQL STSVAALSLV AIATAFKLQN PLNAMQILWI
     NILMDGPPAQ SLGVEPVDHE VMRKPPRKRS DKILTPQVMR RLLINAAFII GGTIYVFIKE
     MTEDGQVTAR DTTMTFTCFV FFDMFSALAC RHATKSIFEI GIFNNKMFNY AVGFSLLGQL
     CAIYIPFFQN IFKTERLSLG DLIYLIVISS SVFIADEVRK YYAKKNTHQD AYYFSMV
//

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