(data stored in ACNUC7421 zone)

SWISSPROT: Q758V2_ASHGO

ID   Q758V2_ASHGO            Unreviewed;       322 AA.
AC   Q758V2;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 94.
DE   RecName: Full=Geranylgeranyl transferase type-2 subunit beta {ECO:0000256|RuleBase:RU365076};
DE            EC=2.5.1.60 {ECO:0000256|RuleBase:RU365076};
GN   ORFNames=AGOS_AEL268W {ECO:0000313|EMBL:AAS52416.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS52416.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS52416.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from
CC       geranylgeranyl diphosphate to both cysteines of proteins with the C-
CC       terminal sequence -XXCC, -XCXC and -CCXX.
CC       {ECO:0000256|RuleBase:RU365076}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] =
CC         diphosphate + S-geranylgeranyl-L-cysteinyl-[protein];
CC         Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537,
CC         ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533,
CC         ChEBI:CHEBI:86021; EC=2.5.1.60;
CC         Evidence={ECO:0000256|RuleBase:RU365076};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU365076};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU365076};
CC   -!- SIMILARITY: Belongs to the protein prenyltransferase subunit beta
CC       family. {ECO:0000256|RuleBase:RU365076}.
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DR   EMBL; AE016818; AAS52416.1; -; Genomic_DNA.
DR   RefSeq; NP_984592.1; NM_209945.1.
DR   STRING; 33169.AAS52416; -.
DR   EnsemblFungi; AAS52416; AAS52416; AGOS_AEL268W.
DR   GeneID; 4620772; -.
DR   KEGG; ago:AGOS_AEL268W; -.
DR   HOGENOM; HOG000180334; -.
DR   InParanoid; Q758V2; -.
DR   KO; K05956; -.
DR   OMA; VKRCQCP; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005968; C:Rab-protein geranylgeranyltransferase complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004663; F:Rab geranylgeranyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0018344; P:protein geranylgeranylation; IBA:GO_Central.
DR   GO; GO:0018342; P:protein prenylation; IBA:GO_Central.
DR   CDD; cd02894; GGTase-II; 1.
DR   InterPro; IPR001330; PFTB_repeat.
DR   InterPro; IPR026873; Ptb1.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF00432; Prenyltrans; 5.
DR   SUPFAM; SSF48239; SSF48239; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q758V2.
DR   SWISS-2DPAGE; Q758V2.
KW   Metal-binding {ECO:0000256|RuleBase:RU365076};
KW   Prenyltransferase {ECO:0000256|RuleBase:RU365076};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Transferase {ECO:0000256|RuleBase:RU365076};
KW   Zinc {ECO:0000256|RuleBase:RU365076}.
SQ   SEQUENCE   322 AA;  35961 MW;  65EE7E71315039BB CRC64;
     MKLLKEKHIS FIKSLDKKHE DFEYWVTEHL RLNGIYWGLT ALCCLGAKDA FDREDIIAFV
     KRCWDKRTGG FAAYEGHDAH LLTTLSGIQV LATYDALDTL TPQEVEQCVN FIEGNQMADG
     SFQGDRFGEV DTRFVYTALS SLSILGRLSA KVVDPAVEFI KRCYNFDGGF GLCPGAESHA
     AQAFTCIGAL AIVGRLGDLS ARQLEDIGWW LCERQVPEGG LNGRPSKLPD VCYSWWVLST
     LAILGKADWI DHEKLGDFIL ASQDPKSGGI SDRPENQVDV FHTLFGIAGL SLMKHDGLVP
     IDPIYCMPYD ITEKFKKYPY ET
//

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