(data stored in ACNUC7421 zone)

SWISSPROT: DPB2_ASHGO

ID   DPB2_ASHGO              Reviewed;         677 AA.
AC   Q758V1;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 87.
DE   RecName: Full=DNA polymerase epsilon subunit B;
DE   AltName: Full=DNA polymerase II subunit 2;
GN   Name=DPB2; OrderedLocusNames=AEL267C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: As accessory component of the DNA polymerase epsilon (DNA
CC       polymerase II) participates in chromosomal DNA replication.
CC       {ECO:0000250|UniProtKB:P24482}.
CC   -!- SUBUNIT: Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3
CC       and DPB4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC       beta, gamma, delta, and epsilon which are responsible for different
CC       reactions of DNA synthesis.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000305}.
DR   EMBL; AE016818; AAS52417.1; -; Genomic_DNA.
DR   RefSeq; NP_984593.1; NM_209946.1.
DR   SMR; Q758V1; -.
DR   STRING; 33169.AAS52417; -.
DR   EnsemblFungi; AAS52417; AAS52417; AGOS_AEL267C.
DR   GeneID; 4620773; -.
DR   KEGG; ago:AGOS_AEL267C; -.
DR   HOGENOM; HOG000246706; -.
DR   InParanoid; Q758V1; -.
DR   KO; K02325; -.
DR   OMA; PGDNDPW; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:EnsemblFungi.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:EnsemblFungi.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; IBA:GO_Central.
DR   GO; GO:0045005; P:DNA-dependent DNA replication maintenance of fidelity; IEA:EnsemblFungi.
DR   GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708; PTHR12708; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q758V1.
DR   SWISS-2DPAGE; Q758V1.
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..677
FT                   /note="DNA polymerase epsilon subunit B"
FT                   /id="PRO_0000071566"
FT   COMPBIAS        430..438
FT                   /note="Poly-Ser"
SQ   SEQUENCE   677 AA;  76553 MW;  BD26AADB1CD35F62 CRC64;
     MDRGSALPAE ISPQLLRPLA YRVLSKKYGL HIKSDGLAQL AKFIGNAFGV DWRRSAETMQ
     FLERFAAIWR EQERGLFVDA LGVDAVTQEL RERNKTAKQR RPARARETTL DALVRPTEAY
     SAVESSGGDV TATEPMDEDT VREEPLDWTH YFKVIDTFSQ QQFTYDVTKR RYRLVQQRES
     AAGPLSTLLR IPSLEANLAQ FPTRYHLVRD RVLRNASFQN DDVYNPLSSM QQLQQQLDAG
     GAPLASTAYM SITQIKNLLG RDGKNFLLLG LIRKDSKGFW SLEDPSGSIE IDISETYPTK
     GTYYVPGCIV LAEGIYSSAG NRFRVSSITH PPGERREAFL EAIGNLDLLG IHGPSNESYI
     SRLDKELKIR LHYLEKELTD HRFVFLGGNI FLDDTMTETA LAKLFDVLEH DPPTVLVLPG
     SFTSTPIYPS SDSKSSSSTA AYRANFDALA KLLSKYERLI NETTFVFIPG DNDPWGSMAY
     LGVAGTLPQH PIPGDFVTKV NRICKHVVWG SNPTRIAYLS QELVIMRDDM CNRFKRNSII
     FPTVEEEQKQ EYMLLQQELQ DDERSSDLSI SQLIKSRDQL PASVQESRKI VKTILDQQHL
     SPFTSQVRPI TWDYDYTLHL SPIPSTMIIC DPTAPKYDVT YNGCKSINPG SFLHKRSVNY
     TEYTPSLRKA TEEEIVV
//

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