(data stored in ACNUC7421 zone)

SWISSPROT: Q758J1_ASHGO

ID   Q758J1_ASHGO            Unreviewed;       505 AA.
AC   Q758J1;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 2.
DT   11-DEC-2019, entry version 105.
DE   SubName: Full=AEL229Wp {ECO:0000313|EMBL:AAS52456.2};
GN   ORFNames=AGOS_AEL229W {ECO:0000313|EMBL:AAS52456.2};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS52456.2, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS52456.2, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
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DR   EMBL; AE016818; AAS52456.2; -; Genomic_DNA.
DR   RefSeq; NP_984632.2; NM_209985.2.
DR   STRING; 33169.AAS52456; -.
DR   EnsemblFungi; AAS52456; AAS52456; AGOS_AEL229W.
DR   GeneID; 4620814; -.
DR   KEGG; ago:AGOS_AEL229W; -.
DR   HOGENOM; HOG000094160; -.
DR   InParanoid; Q758J1; -.
DR   KO; K11121; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0070403; F:NAD+ binding; IBA:GO_Central.
DR   GO; GO:0017136; F:NAD-dependent histone deacetylase activity; IBA:GO_Central.
DR   GO; GO:0006348; P:chromatin silencing at telomere; IEA:EnsemblFungi.
DR   GO; GO:0009299; P:mRNA transcription; IEA:EnsemblFungi.
DR   GO; GO:0098781; P:ncRNA transcription; IEA:EnsemblFungi.
DR   GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IEA:EnsemblFungi.
DR   GO; GO:0046459; P:short-chain fatty acid metabolic process; IEA:EnsemblFungi.
DR   Gene3D; 3.30.1600.10; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   4: Predicted;
DR   PRODOM; Q758J1.
DR   SWISS-2DPAGE; Q758J1.
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   DOMAIN          46..354
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
FT   REGION          371..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          478..505
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..414
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..495
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   505 AA;  57490 MW;  8C359818D726E152 CRC64;
     MPSLIQSQES FDEELPSVLE KKATPKPQLQ TEKLKHIELD SDNVDEELLS MINRQIGRSR
     KIMVLTGAGI SCSAGIPDFR SSGGLYNMVK KQYPEVQIRS GQEMFDISLF REEEKISVFA
     TFMDSLHSSA IQAKPTRAHE FIAHLKNRGK LLRCYTQNID GLEEHLGLEM SHSVDPGASF
     NTQWKNLDVV QLHGDLNSLS CTQCFEVFNW TRSWKRILKA GELPPCPRCC AFNQERENQG
     KRLRNSVGIL RPNIVLYGEN HPSCEFITQG LNMDIAKGKP DLLIIMGTSL KVDGVKKLVK
     SISRQVHERS GIVLLINSTT IGDCNWHGII DYQILAECDA WVADLKKRLP DFFMTQQQVD
     KLRQLKREAS ELKKRQRKEQ YLFPQAERRN IPNTPPSTPS PTKRRRAAAN TPSSTLRTLK
     ETVVTLPPTQ VPSLQRDQRD TTMNKIYMKL IKDDDHYAKL TDMPEEELMQ SVIAEKKAIA
     PSKNRKVKDS QSMDFDEVPT DVDEP
//

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