(data stored in ACNUC7421 zone)

SWISSPROT: Q758A8_ASHGO

ID   Q758A8_ASHGO            Unreviewed;       301 AA.
AC   Q758A8;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 93.
DE   RecName: Full=S-formylglutathione hydrolase {ECO:0000256|RuleBase:RU363068};
DE            EC=3.1.2.12 {ECO:0000256|RuleBase:RU363068};
GN   ORFNames=AGOS_AEL156W {ECO:0000313|EMBL:AAS52529.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS52529.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS52529.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Serine hydrolase involved in the detoxification of
CC       formaldehyde. {ECO:0000256|RuleBase:RU363068}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + S-formylglutathione = formate + glutathione + H(+);
CC         Xref=Rhea:RHEA:14961, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:57688, ChEBI:CHEBI:57925; EC=3.1.2.12;
CC         Evidence={ECO:0000256|RuleBase:RU363068};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU363068}.
CC   -!- SIMILARITY: Belongs to the esterase D family.
CC       {ECO:0000256|RuleBase:RU363068}.
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DR   EMBL; AE016818; AAS52529.1; -; Genomic_DNA.
DR   RefSeq; NP_984705.1; NM_210058.1.
DR   STRING; 33169.AAS52529; -.
DR   ESTHER; ashgo-q758a8; A85-EsteraseD-FGH.
DR   MEROPS; S09.A39; -.
DR   EnsemblFungi; AAS52529; AAS52529; AGOS_AEL156W.
DR   GeneID; 4620890; -.
DR   KEGG; ago:AGOS_AEL156W; -.
DR   HOGENOM; HOG000263929; -.
DR   InParanoid; Q758A8; -.
DR   KO; K01070; -.
DR   OMA; QKAFAGY; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0018738; F:S-formylglutathione hydrolase activity; IBA:GO_Central.
DR   GO; GO:0046294; P:formaldehyde catabolic process; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000801; Esterase_put.
DR   InterPro; IPR014186; S-formylglutathione_hydrol.
DR   PANTHER; PTHR10061; PTHR10061; 1.
DR   Pfam; PF00756; Esterase; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   TIGRFAMs; TIGR02821; fghA_ester_D; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q758A8.
DR   SWISS-2DPAGE; Q758A8.
KW   Cytoplasm {ECO:0000256|RuleBase:RU363068};
KW   Hydrolase {ECO:0000256|RuleBase:RU363068};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Serine esterase {ECO:0000256|RuleBase:RU363068}.
FT   ACT_SITE        161
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
FT   ACT_SITE        243
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
FT   ACT_SITE        278
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
SQ   SEQUENCE   301 AA;  33670 MW;  CDF22A859DDFFA40 CRC64;
     MGFKVNAELR SCGGRLLKLS HVSDACKSTM DVNVYLPVQY YKKTERAIPT IYYLSGLTCT
     PQNASEKAFW QAQADKYGFA VVFPDTSPRG VEIPKDPEDS WDFGEGAGFY VNATMEPFAR
     YYNMYDYIHN ELPGLLAKHF SAGPQNAKVD FLENIGITGH SMGGFGALSG YLKNYRNAKW
     RFKSCSAFAP IVNPSVVPWG QKAFRGYLGE DKALWEQYDP CCLVKKVENA GHDTILIHVG
     TSDPFLEKHL KPELLAEAIK GTSWEGKVSI NLVDGFDHSY YFVSTFVPEH AKYHAEKLGL
     V
//

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