(data stored in ACNUC7421 zone)

SWISSPROT: GON7_ASHGO

ID   GON7_ASHGO              Reviewed;         113 AA.
AC   Q758A4;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 80.
DE   RecName: Full=EKC/KEOPS complex subunit GON7;
GN   Name=GON7; OrderedLocusNames=AEL144W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC       formation of a threonylcarbamoyl group on adenosine at position 37
CC       (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC       is probably involved in the transfer of the threonylcarbamoyl moiety of
CC       threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely
CC       plays a supporting role to the catalytic subunit KAE1 in the complex.
CC       The EKC/KEOPS complex also promotes both telomere uncapping and
CC       telomere elongation. The complex is required for efficient recruitment
CC       of transcriptional coactivators (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the EKC/KEOPS complex composed of at least BUD32,
CC       CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GON7 family. {ECO:0000305}.
DR   EMBL; AE016818; AAS52541.1; -; Genomic_DNA.
DR   RefSeq; NP_984717.1; NM_210070.1.
DR   SMR; Q758A4; -.
DR   STRING; 33169.AAS52541; -.
DR   EnsemblFungi; AAS52541; AAS52541; AGOS_AEL144W.
DR   GeneID; 4620904; -.
DR   KEGG; ago:AGOS_AEL144W; -.
DR   HOGENOM; HOG000247898; -.
DR   InParanoid; Q758A4; -.
DR   KO; K15903; -.
DR   OMA; QDHLNIF; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0000408; C:EKC/KEOPS complex; IEA:EnsemblFungi.
DR   GO; GO:0000790; C:nuclear chromatin; IEA:EnsemblFungi.
DR   GO; GO:0031490; F:chromatin DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000032; P:cell wall mannoprotein biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IEA:EnsemblFungi.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR014849; EKC/KEOPS_Gon7.
DR   Pfam; PF08738; Gon7; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q758A4.
DR   SWISS-2DPAGE; Q758A4.
KW   Activator; Chromosome; Nucleus; Reference proteome; Telomere;
KW   Transcription; Transcription regulation; tRNA processing.
FT   CHAIN           1..113
FT                   /note="EKC/KEOPS complex subunit GON7"
FT                   /id="PRO_0000278919"
SQ   SEQUENCE   113 AA;  12247 MW;  3C0979D7041483E1 CRC64;
     MQPPTATYCT PEGDSHAFTV VPDAPRYRTT DGTTSGPSAY VLQAGQIDRD RPSPPKLDAQ
     GEPTALSRLR MHLTGLQDDI NSFLTAEMQR AKNKKQKIDD TQEQRATGGS TAA
//

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