(data stored in ACNUC7421 zone)

SWISSPROT: Q757N4_ASHGO

ID   Q757N4_ASHGO            Unreviewed;       344 AA.
AC   Q757N4;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 2.
DT   11-DEC-2019, entry version 88.
DE   RecName: Full=Histidinol-phosphatase {ECO:0000256|RuleBase:RU366003};
DE            Short=HolPase {ECO:0000256|RuleBase:RU366003};
DE            EC=3.1.3.15 {ECO:0000256|RuleBase:RU366003};
GN   ORFNames=AGOS_AEL022W {ECO:0000313|EMBL:AAS52663.2};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS52663.2, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS52663.2, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-histidinol phosphate = L-histidinol + phosphate;
CC         Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=3.1.3.15;
CC         Evidence={ECO:0000256|RuleBase:RU366003};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
CC       {ECO:0000256|RuleBase:RU366003}.
CC   -!- SIMILARITY: Belongs to the PHP hydrolase family. HisK subfamily.
CC       {ECO:0000256|RuleBase:RU366003}.
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DR   EMBL; AE016818; AAS52663.2; -; Genomic_DNA.
DR   RefSeq; NP_984839.2; NM_210193.2.
DR   STRING; 33169.AAS52663; -.
DR   EnsemblFungi; AAS52663; AAS52663; AGOS_AEL022W.
DR   GeneID; 4621037; -.
DR   KEGG; ago:AGOS_AEL022W; -.
DR   HOGENOM; HOG000170774; -.
DR   InParanoid; Q757N4; -.
DR   KO; K04486; -.
DR   OMA; DFHPGTE; -.
DR   UniPathway; UPA00031; UER00013.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0004401; F:histidinol-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0000105; P:histidine biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR010140; Histidinol_P_phosphatase_HisJ.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   PANTHER; PTHR21039; PTHR21039; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR01856; hisJ_fam; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q757N4.
DR   SWISS-2DPAGE; Q757N4.
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU366003};
KW   Histidine biosynthesis {ECO:0000256|RuleBase:RU366003};
KW   Hydrolase {ECO:0000256|RuleBase:RU366003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   DOMAIN          15..254
FT                   /note="PHP"
FT                   /evidence="ECO:0000259|Pfam:PF02811"
SQ   SEQUENCE   344 AA;  39090 MW;  16F5474EFFE146BD CRC64;
     MCRRTSQRNL RMFSHHSHSG EYVAHGADTL EAVVAEALRQ GFHTYCLTEH MPRLDEAYLY
     PEERSGAAAR DLRGLAELFG RYVEHAARLR QHVDGMAVLV GMEAEACDRQ HVAYAKRLLQ
     DFGSHVQFCV GSVHHVYGIP IDFSQTLWDS ALQQAGGNLK RLLADYFDWQ YYMLRELQPE
     VVGHFDLIRL YLPRDRFWVE LGTGAVSDTY LGGNWTHIAL VSARIVSLWE DVQSRVVRNL
     EYIASYGGLV EINSAGLRKG LADPYPHRDV ALLVKRYAGA RFVLSDDAHS VSQVGTEYVR
     TLEYVENVLQ LEGLFYLAEA SSGPTALEAK YMSLQEIKES RFWK
//

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