(data stored in ACNUC7421 zone)

SWISSPROT: DBP6_ASHGO

ID   DBP6_ASHGO              Reviewed;         607 AA.
AC   Q751D1;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 100.
DE   RecName: Full=ATP-dependent RNA helicase DBP6;
DE            EC=3.6.4.13;
GN   Name=DBP6; OrderedLocusNames=AGL225C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of 60S
CC       ribosomal subunits and is required for the normal formation of 25S and
CC       5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associated with pre-ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC       family of RNA helicases and controls ATP binding and hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX51/DBP6
CC       subfamily. {ECO:0000305}.
DR   EMBL; AE016820; AAS54266.1; -; Genomic_DNA.
DR   RefSeq; NP_986442.1; NM_211504.1.
DR   SMR; Q751D1; -.
DR   STRING; 33169.AAS54266; -.
DR   PRIDE; Q751D1; -.
DR   EnsemblFungi; AAS54266; AAS54266; AGOS_AGL225C.
DR   GeneID; 4622735; -.
DR   KEGG; ago:AGOS_AGL225C; -.
DR   HOGENOM; HOG000203294; -.
DR   InParanoid; Q751D1; -.
DR   KO; K14807; -.
DR   OMA; ATMTRDI; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q751D1.
DR   SWISS-2DPAGE; Q751D1.
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW   Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..607
FT                   /note="ATP-dependent RNA helicase DBP6"
FT                   /id="PRO_0000227948"
FT   DOMAIN          208..388
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          419..578
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   NP_BIND         221..228
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   MOTIF           184..192
FT                   /note="Q motif"
FT   MOTIF           328..331
FT                   /note="DEAD box"
SQ   SEQUENCE   607 AA;  67047 MW;  5D02DA173B8196A3 CRC64;
     MFAARFDPSR HYEEGDTAPP APSLPMKRSR DAQQDESESE MSSAESEDEA MQLDDEEEVV
     DSKGKENHGS DSIGTGEADK RHQSVLSRFQ RTISVQDKLD SDAIVGSDSE EEPAKMHGLV
     PIAQPAIVRD TLAQDSRKER KLLAWSNTTK IHYDSTMTKP FAAYKDILST SLLANVEGGF
     SRTAFPIQTA LLDSVLPLMS QAYSVSKRYY TRKVGDILVN ASTGSGKTLA YAMLLIHILS
     RRTVNKLRAV ILVPTKLLVH QVYDTVQALA KGSSVVVAVS KMDTSLKEES AKLKAQEPDV
     LIITPGRLVD HLNMQTFSLK NLKFLVLDEA DRLLNQSFQN WCIELMTRLN AERPFKGPGN
     VIKMIFSATL TTNTERLHDL QLHNPKLFLM GSQLYHMPAQ LQEYNLPIPT SKSYAKPLIL
     LRLLPLLSTE SLRILVFVKS NEASIRLAAL LTAMVGNGLS AVSTTVGSIN NNNSKATNRK
     LIEAFAAGAS GHCSILVSTD LMSRGLDISG ISHVINYDLP ISSQQYVHRC GRTARANTSG
     TAVNLLVGKG EQNFWKDHID SDISRAPDGS HLFFDEEQRE QLVSLSEEDT ATYKKCLEEL
     KKSVLGR
//

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