(data stored in ACNUC7421 zone)

SWISSPROT: SCC2_ASHGO

ID   SCC2_ASHGO              Reviewed;        1479 AA.
AC   Q750S2;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 88.
DE   RecName: Full=Sister chromatid cohesion protein 2;
GN   Name=SCC2; OrderedLocusNames=AGL133W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Plays a structural role in chromatin. Probably involved in
CC       sister chromatid cohesion, possibly by interacting with the cohesin
CC       complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCC2/Nipped-B family. {ECO:0000305}.
DR   EMBL; AE016820; AAS54358.1; -; Genomic_DNA.
DR   RefSeq; NP_986534.1; NM_211596.1.
DR   PDB; 5C6G; X-ray; 2.60 A; B/D=1-218.
DR   PDB; 5ME3; X-ray; 2.85 A; A/B=378-1479.
DR   PDBsum; 5C6G; -.
DR   PDBsum; 5ME3; -.
DR   SMR; Q750S2; -.
DR   STRING; 33169.AAS54358; -.
DR   EnsemblFungi; AAS54358; AAS54358; AGOS_AGL133W.
DR   GeneID; 4622833; -.
DR   KEGG; ago:AGOS_AGL133W; -.
DR   HOGENOM; HOG000154264; -.
DR   InParanoid; Q750S2; -.
DR   KO; K06672; -.
DR   OMA; AIKCLSM; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005729; C:2-micrometer circle DNA; IEA:EnsemblFungi.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000790; C:nuclear chromatin; IBA:GO_Central.
DR   GO; GO:0000228; C:nuclear chromosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0090694; C:Scc2-Scc4 cohesin loading complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0043515; F:kinetochore binding; IEA:EnsemblFungi.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006302; P:double-strand break repair; IBA:GO_Central.
DR   GO; GO:0034087; P:establishment of mitotic sister chromatid cohesion; IBA:GO_Central.
DR   GO; GO:0071169; P:establishment of protein localization to chromatin; IBA:GO_Central.
DR   GO; GO:0007076; P:mitotic chromosome condensation; IBA:GO_Central.
DR   GO; GO:0007064; P:mitotic sister chromatid cohesion; IBA:GO_Central.
DR   GO; GO:1905406; P:positive regulation of mitotic cohesin loading; IBA:GO_Central.
DR   GO; GO:0070550; P:rDNA condensation; IBA:GO_Central.
DR   GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IBA:GO_Central.
DR   GO; GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0071733; P:transcriptional activation by promoter-enhancer looping; IBA:GO_Central.
DR   GO; GO:0070058; P:tRNA gene clustering; IEA:EnsemblFungi.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR026003; Cohesin_HEAT.
DR   InterPro; IPR024986; Nipped-B_C.
DR   InterPro; IPR033031; SCC2/Nipped-B.
DR   PANTHER; PTHR21704; PTHR21704; 1.
DR   Pfam; PF12765; Cohesin_HEAT; 1.
DR   Pfam; PF12830; Nipped-B_C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q750S2.
DR   SWISS-2DPAGE; Q750S2.
KW   3D-structure; Cell cycle; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..1479
FT                   /note="Sister chromatid cohesion protein 2"
FT                   /id="PRO_0000218602"
FT   REPEAT          681..718
FT                   /note="HEAT 1"
FT   REPEAT          720..757
FT                   /note="HEAT 2"
FT   REPEAT          792..829
FT                   /note="HEAT 3"
FT   REPEAT          1117..1154
FT                   /note="HEAT 4"
FT   REPEAT          1229..1266
FT                   /note="HEAT 5"
FT   TURN            5..8
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   STRAND          9..11
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   HELIX           15..19
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   HELIX           31..35
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   STRAND          41..47
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   HELIX           58..62
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   HELIX           99..101
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   STRAND          102..104
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   HELIX           107..112
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   TURN            113..115
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   HELIX           121..123
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   STRAND          124..126
FT                   /evidence="ECO:0000244|PDB:5C6G"
FT   STRAND          424..427
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   TURN            428..430
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   STRAND          431..434
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           435..444
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           450..455
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           461..493
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   TURN            497..499
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           501..514
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           523..535
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           546..568
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           579..583
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           586..602
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   STRAND          605..607
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           609..627
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           639..649
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   TURN            664..666
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           667..674
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           678..681
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           683..692
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           693..695
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           699..715
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           717..721
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           723..734
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           738..749
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           755..757
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           758..761
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           762..764
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           770..786
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           790..802
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           809..823
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           825..828
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           834..852
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           856..868
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   TURN            869..871
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           873..875
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           878..902
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           914..926
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           935..941
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           943..946
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           953..965
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           973..986
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           992..1009
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1013..1024
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1027..1034
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1045..1059
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   STRAND          1073..1076
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1078..1088
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1096..1112
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1114..1118
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1120..1132
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1135..1156
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1187..1205
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1210..1226
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1231..1233
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1235..1241
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1247..1263
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1265..1270
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1272..1286
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   TURN            1288..1290
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1291..1293
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1297..1305
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1309..1326
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1334..1350
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1356..1378
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1381..1383
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1386..1388
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1391..1414
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1419..1423
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1433..1436
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   STRAND          1437..1440
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1451..1454
FT                   /evidence="ECO:0000244|PDB:5ME3"
FT   HELIX           1464..1472
FT                   /evidence="ECO:0000244|PDB:5ME3"
SQ   SEQUENCE   1479 AA;  170017 MW;  5DA48A04CA8E4D3D CRC64;
     MSTFPGEDTR IPKRISEALS HQPLNHLVPK RELSRLLSKP VQISVQLESE DAFEEVPEEL
     WQYPHPIDLD PLRLEESQPL RFRRPRGARL DYREDSSEIA DLPGMGQLAR ACLSGTQLVD
     SAAIVESIES NAKKRKQTLA IGDVEMVSPD KKTKVMASVS PVSLNRVALG SQHLKTLERL
     MQYIGADESS AEFGDFEYWI TLEDRATHIL SEQCIDKLHI VFRNILSIPA VWTELDVSLL
     QRIMDVCVST ITICLEKIEL KEYSHDYTLI AFGSSMVVFF IFLLDQNDRR LQLEQYMMVP
     LQFLTFTADN LEEEFDRGGN GVERSLAMLH STLDVFYMYI SNKPKLDDGL VVKLVYMFTE
     LIMSTWSHNV SSVSLQNHIG NVKTIGMKSI EVLFEKLPEQ RLFIIDELLS HLDNLPNTRS
     QKRMKNIGKN LHITHFSYIM LSILQVWNNY DYCSNLVSPD TEQLHDLIAH HAATQSDLEF
     AADHIIDTIL KKCFSNISKY RFVFDQFVTD MTTVVTLPDW PVSDLILARL LKKLLSIFNP
     QSQKHINIES VALQGIGLIG STILDIRLSS NSNPTANLIH LFNYPEDIDG LFKAYRTCLA
     YCTNSVQHHT PYKFLWCKQL DVLTKLKEMD KESQGWGSKL QQKFLSLIES IHLPLEQAAN
     LGAVEILPTY CSTLLTSELI NMYEPYLKLV LSLLERHKVK LRSGAIRCLA LLISKDKNML
     YTPIVKETIE NRLTDSSPLV KDAILELIEL GSSYIDFYQH ININYNDDSM LVRKHVLRMN
     QIIYDDTEDI IIKAYVASRI LRRIEDEEDV IIETARSELL KRWILSIQCP NAKPELQIKN
     CRVSIRVIAQ LLVGGDKICD LFEHFLIFYV LNKNAHTEDQ NKLISSSLCL LTDQVIEMVI
     ENEAADVDNQ REEEGRNIMK FLSVLSSCQD SFITKDHITA LYPYLHSDTK SDFQLHILKV
     YRNTFEQLSH FKPKFLYDLE TTILSRLPRM NVRELDEAIP LSWSLSRHRK DDTRICKACA
     SCLGQLSPYI ANATTDPSAV RPDGKLQRLL YLATGFARFC SFENTEGKFP NLKTRENIFE
     YVTKCLLMFT KENIHHVIRR IATKNLVKIA SRYPKLFNSR HVLTVLDTQF EKGILDIQLV
     VLESLYDFFL AEERRSLIQV GVDGTISSNN ELRKVVANHT KSDSINDGIC SALVSRYLDK
     ILKICLIADL NNAMVAIRFL KQILTYGYTN PSLCVPTVIA LTASPNSYMR DLSSEMFSEL
     LQGYESMAFN CLNQGIRLGT EYAVKIRPKQ FHEDSMFLRR LQQLMSTNKR NRSKFLKVVK
     KTVFSNYLST SVNYEESCYH IIYLLHNLSK ISYDNMLELY EMLRSVISVS EYFSDRISER
     LDGFQSNQNT AAEVSAIIVT RLSIEEFKRF MFEQHHLSEA KLTLLDATDD ENLRNKSVAA
     LDDQVGSLHM ENIFLGYENP INNKDYCWKY ISTLHRDEI
//

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