(data stored in ACNUC7421 zone)

SWISSPROT: CDC42_ASHGO

ID   CDC42_ASHGO             Reviewed;         191 AA.
AC   Q9HF56;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   11-DEC-2019, entry version 109.
DE   RecName: Full=Cell division control protein 42;
DE   Flags: Precursor;
GN   Name=CDC42; OrderedLocusNames=AGL093W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=11156982;
RA   Wendland J., Philippsen P.;
RT   "Cell polarity and hyphal morphogenesis are controlled by multiple rho-
RT   protein modules in the filamentous ascomycete Ashbya gossypii.";
RL   Genetics 157:601-610(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in development of cell polarity during the cell
CC       division cycle. Required for the establishment of actin polarization in
CC       germ cells. {ECO:0000269|PubMed:11156982}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family. CDC42
CC       subfamily. {ECO:0000305}.
DR   EMBL; AF210627; AAG41247.1; -; Genomic_DNA.
DR   EMBL; AE016820; AAS54397.1; -; Genomic_DNA.
DR   RefSeq; NP_986573.1; NM_211635.1.
DR   SMR; Q9HF56; -.
DR   STRING; 33169.AAS54397; -.
DR   PRIDE; Q9HF56; -.
DR   EnsemblFungi; AAS54397; AAS54397; AGOS_AGL093W.
DR   GeneID; 4622872; -.
DR   KEGG; ago:AGOS_AGL093W; -.
DR   HOGENOM; HOG000233974; -.
DR   InParanoid; Q9HF56; -.
DR   KO; K04393; -.
DR   OMA; GYLADHM; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR   GO; GO:0005935; C:cellular bud neck; IEA:EnsemblFungi.
DR   GO; GO:0005934; C:cellular bud tip; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0000131; C:incipient cellular bud site; IEA:EnsemblFungi.
DR   GO; GO:0043332; C:mating projection tip; IEA:EnsemblFungi.
DR   GO; GO:0031965; C:nuclear membrane; IEA:EnsemblFungi.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005940; C:septin ring; IEA:EnsemblFungi.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0007118; P:budding cell apical bud growth; IEA:EnsemblFungi.
DR   GO; GO:0007119; P:budding cell isotropic bud growth; IEA:EnsemblFungi.
DR   GO; GO:0032488; P:Cdc42 protein signal transduction; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0030031; P:cell projection assembly; IBA:GO_Central.
DR   GO; GO:0000747; P:conjugation with cellular fusion; IEA:EnsemblFungi.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0030010; P:establishment of cell polarity; IEA:EnsemblFungi.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR   GO; GO:0001403; P:invasive growth in response to glucose limitation; IEA:EnsemblFungi.
DR   GO; GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IEA:EnsemblFungi.
DR   GO; GO:0045921; P:positive regulation of exocytosis; IEA:EnsemblFungi.
DR   GO; GO:2000222; P:positive regulation of pseudohyphal growth; IEA:EnsemblFungi.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR   GO; GO:0007096; P:regulation of exit from mitosis; IEA:EnsemblFungi.
DR   GO; GO:0060178; P:regulation of exocyst localization; IEA:EnsemblFungi.
DR   GO; GO:0031384; P:regulation of initiation of mating projection growth; IEA:EnsemblFungi.
DR   GO; GO:0032889; P:regulation of vacuole fusion, non-autophagic; IEA:EnsemblFungi.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   GO; GO:0031106; P:septin ring organization; IEA:EnsemblFungi.
DR   CDD; cd01874; Cdc42; 1.
DR   InterPro; IPR037874; Cdc42.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q9HF56.
DR   SWISS-2DPAGE; Q9HF56.
KW   Cell cycle; Cell division; Cell membrane; GTP-binding; Lipoprotein;
KW   Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome.
FT   CHAIN           1..188
FT                   /note="Cell division control protein 42"
FT                   /id="PRO_0000198951"
FT   PROPEP          189..191
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000281281"
FT   NP_BIND         10..17
FT                   /note="GTP"
FT                   /evidence="ECO:0000250"
FT   NP_BIND         57..61
FT                   /note="GTP"
FT                   /evidence="ECO:0000250"
FT   NP_BIND         115..118
FT                   /note="GTP"
FT                   /evidence="ECO:0000250"
FT   MOTIF           32..40
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         188
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           188
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   191 AA;  21470 MW;  E73389C1847CD5B9 CRC64;
     MQTLKCVVVG DGAVGKTCLL ISYTTNQFPA DYVPTVFDNY AVTVMIGDEP YTLGLFDTAG
     QEDYDRLRPL SYPSTDVFLV CFSVVSPPSF ENVKEKWFPE VHHHCPGVPC LIVGTQIDLR
     ENKMVIEKLQ RQRLRPITPE QGEKFARELR AVKYVECSAL TQRGLKNVFD EAIVAALEPP
     VIKKSKKCTI L
//

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