(data stored in ACNUC7421 zone)

SWISSPROT: Q750I3_ASHGO

ID   Q750I3_ASHGO            Unreviewed;       723 AA.
AC   Q750I3;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 119.
DE   SubName: Full=AGL032Cp {ECO:0000313|EMBL:AAS54458.1};
GN   ORFNames=AGOS_AGL032C {ECO:0000313|EMBL:AAS54458.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS54458.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS54458.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|RuleBase:RU000590, ECO:0000256|SAAS:SAAS01079563}.
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DR   EMBL; AE016820; AAS54458.1; -; Genomic_DNA.
DR   RefSeq; NP_986634.1; NM_211696.1.
DR   STRING; 33169.AAS54458; -.
DR   MEROPS; M24.003; -.
DR   EnsemblFungi; AAS54458; AAS54458; AGOS_AGL032C.
DR   GeneID; 4622933; -.
DR   KEGG; ago:AGOS_AGL032C; -.
DR   HOGENOM; HOG000255713; -.
DR   InParanoid; Q750I3; -.
DR   KO; K01262; -.
DR   OMA; YRPGKWG; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   GO; GO:0034396; P:negative regulation of transcription from RNA polymerase II promoter in response to iron; IEA:EnsemblFungi.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.40.350.10; -; 2.
DR   Gene3D; 3.90.230.10; -; 1.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF53092; SSF53092; 1.
DR   SUPFAM; SSF55920; SSF55920; 1.
DR   PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q750I3.
DR   SWISS-2DPAGE; Q750I3.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01079575};
KW   Metal-binding {ECO:0000256|RuleBase:RU000590,
KW   ECO:0000256|SAAS:SAAS01079562};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   DOMAIN          97..240
FT                   /note="Creatinase_N"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          440..649
FT                   /note="Peptidase_M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          660..720
FT                   /note="Peptidase_M24_C"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
FT   REGION          59..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          448..471
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   723 AA;  80943 MW;  911BB1C72140BAAF CRC64;
     MTTRTVDVKG SMASMSGSSM LATMVPTVGQ RPFKPCANCN CTPGQLWRQG RRTSQFLRRI
     SNSRKASSPA GSRGGSNESI YSSDSLWQTK LVTTTERLLA LRKQMAAEEL CCYVIPSEDE
     HNSEYVGPAD LRRQFITGFS GSAGVACVSR DMLNFNTDSP EGKAVLNTDG RYFNQARQEL
     DHNWTLLRQG EDSMTWVDWC LNEAYDMSIS LGGKPARIGI DPKLIVDSRV LSIKKQIADK
     TKGTNAVIEL VPVEKNLVDA IWAEFEEPPK RELYPLVLLP SVISGESYQT KRQRLMKQLK
     ENYAGHTAFC VTALDEICWF LNIRGSDVEY NPVFYAYFVI HQDSSVLYTD NPLSEEIEKY
     LADNDVAVKS YAEVWSDLKE LDVKLESAKE AILLPSTASW AITSNVSNAT YKLVSSPLAA
     FKAVKNEVEI NNARASQVKE AVCLVQFFAW LEEELVQKEK LIDEYKAATK LHEIRKTQKN
     FVGNSFETIS ASGSNAAVIH YSPPSEGSAM ICPYKIYLCD SGSQFLEGTT DITRTLHFST
     PTQEEVDSYT LVLKGNLALE RLVFPEGTTG NSIDVIARQF LWEQGLDYRH GTGHGIGSFL
     NVHEGPIGIG PSVAYAKYPL AKGNIISNEP GFYKDGEFGV RIENDMLVLE AEDLKFGTRK
     FLKFENITLV PYCRKLINPK LLTPEEIQQL NNYNSRIWSA VASHLQPQSI SYKWLKRETA
     VYR
//

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