(data stored in ACNUC7421 zone)

SWISSPROT: Q750G1_ASHGO

ID   Q750G1_ASHGO            Unreviewed;      1178 AA.
AC   Q750G1;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 94.
DE   SubName: Full=AGL008Wp {ECO:0000313|EMBL:AAS54482.1};
GN   ORFNames=AGOS_AGL008W {ECO:0000313|EMBL:AAS54482.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS54482.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS54482.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
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DR   EMBL; AE016820; AAS54482.1; -; Genomic_DNA.
DR   RefSeq; NP_986658.1; NM_211720.2.
DR   STRING; 33169.AAS54482; -.
DR   EnsemblFungi; AAS54482; AAS54482; AGOS_AGL008W.
DR   GeneID; 4622957; -.
DR   KEGG; ago:AGOS_AGL008W; -.
DR   HOGENOM; HOG000036674; -.
DR   InParanoid; Q750G1; -.
DR   KO; K12385; -.
DR   OMA; VFPYSKF; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098772; F:molecular function regulator; IEA:EnsemblFungi.
DR   GO; GO:0032934; F:sterol binding; IEA:EnsemblFungi.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0015918; P:sterol transport; IEA:EnsemblFungi.
DR   InterPro; IPR032190; NPC1_N.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   Pfam; PF16414; NPC1_N; 1.
DR   Pfam; PF02460; Patched; 1.
DR   PROSITE; PS50156; SSD; 1.
PE   4: Predicted;
DR   PRODOM; Q750G1.
DR   SWISS-2DPAGE; Q750G1.
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..1178
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004285305"
FT   TRANSMEM        261..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        563..581
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        590..614
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        620..641
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        668..691
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        697..723
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        756..777
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1004..1024
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1030..1053
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1060..1086
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1106..1125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1137..1160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          562..722
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   1178 AA;  131153 MW;  F30AC82F34784F9F CRC64;
     MRTNEMLSVI LVGVYLLVGL PCGRAAAQCA MYGNCGRQSA FGAELPCPVG ADFTPEPLSA
     DDSGFLASVC GPEWGSMDYV CCTRDQMVKL RANLKKAEAI IASCPACAKN FAATFCHFTC
     SPAQRQFLDV KETELSTIGK RIVTEVDFYV ESEYGESFYD SCKNVKFSST NGYAMDLIGG
     GAHNYKEFLN FLGDKKPSLG GSPFQINFKY SSETGQAPLN EKTYACNDTE FRCACADCQE
     SCPVLKPVKS GQCKVGKLPC LSFGALVAYG GAALALLLSY LYVSRAKGDG VLLQDDAMGD
     DNEELNRQAE DELFHEYPTS RYRLNDVLAD HLGSVAAYCI KYPYHVLGAT FAVVLILSSL
     IPFFGRLETD PVALWVSKRS PRFIEKQYFD ENFGPFYRME QIFIANDNGP VLSYEHLDWW
     FTIEKEITSG LQSSDNTTFQ DLCLRPTSDS TCVIQSVTQY FDGILPPKST WLEDLKTCAE
     SPVSCLPSFQ QPLNSKLLFS HENITESNAL VISLPVDNHT QSAELWEQTL EDYLSKLDVP
     KGLRLSFSTE SSLSKELGKN NDVTIVLISY VIMFFYASWA LKNKMGKQRF LLGGTGILIV
     FCSILSAVGM LSALGLSSTL IIAEVIPFLI LAIGVDNIFL LTGEYDRTTA GNTSLSIEDR
     ILISVRKIAP SIVTSVVCQT VCFLLAAFVG MPAVRNFALY SAAALFFNFL FQITAFVSIL
     TLYENKYESY LSNTSLEQEP PFFLPKLRNV ILKKSTAIVF IVWSLASIVF LPYISIGLDQ
     KMAVPQDSHL TTYFEDVSQY LNVGPPVYFV LRNLDLTKRE NQKKICGKFT TCNEFSLANV
     LEQERNRSTI TEPLTNWYDD FMMFLNPALD ECCRLKKGSQ EVCPPRYPFR RCQTCYPPGT
     WDYDMTDFPE DGEFMRFFKI WIDAPSEPCP LGGKAPYSSS IIYNDSVIEA SMFRSYHSPL
     RTQKDYIAAY KDAERITGEF KDLDVFAYSP VYIFFDQYRS LVSLTLKLLA VALITMFWIS
     LVMLGSVSTA LLLTGTVFMI LVDIGASMVL FNIPLNAVSL VNLVICVGLA VEFCIHIARA
     FTLVPVGIKN SRPSRSVYAL ASVGESVFRG ITMTKLIGVC ILFFAQSKIF QVFYFRMWLS
     LILIASLHAL IFLPTALAFL GGQSYVEGNS EVRLVDAE
//

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