(data stored in ACNUC10821 zone)

SWISSPROT: IOLC_LISMF

ID   IOLC_LISMF              Reviewed;         325 AA.
AC   Q723S9;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   08-MAY-2019, entry version 84.
DE   RecName: Full=5-dehydro-2-deoxygluconokinase {ECO:0000255|HAMAP-Rule:MF_01668};
DE            EC=2.7.1.92 {ECO:0000255|HAMAP-Rule:MF_01668};
DE   AltName: Full=2-deoxy-5-keto-D-gluconate kinase {ECO:0000255|HAMAP-Rule:MF_01668};
DE            Short=DKG kinase {ECO:0000255|HAMAP-Rule:MF_01668};
GN   Name=iolC {ECO:0000255|HAMAP-Rule:MF_01668};
GN   OrderedLocusNames=LMOf2365_0397;
OS   Listeria monocytogenes serotype 4b (strain F2365).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=265669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F2365;
RX   PubMed=15115801; DOI=10.1093/nar/gkh562;
RA   Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T.,
RA   Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T.,
RA   Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J.,
RA   Brinkac L.M., Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R.,
RA   Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N.,
RA   Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A.,
RA   Bayles D.O., Luchansky J.B., Fraser C.M.;
RT   "Whole genome comparisons of serotype 4b and 1/2a strains of the food-
RT   borne pathogen Listeria monocytogenes reveal new insights into the
RT   core genome components of this species.";
RL   Nucleic Acids Res. 32:2386-2395(2004).
CC   -!- FUNCTION: Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-
CC       gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-
CC       dehydro-2-deoxy-D-gluconate (DKGP). {ECO:0000255|HAMAP-
CC       Rule:MF_01668}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-dehydro-2-deoxy-D-gluconate + ATP = 6-phospho-5-
CC         dehydro-2-deoxy-D-gluconate + ADP + H(+); Xref=Rhea:RHEA:13497,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16669, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57949, ChEBI:CHEBI:456216; EC=2.7.1.92;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01668};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-
CC       CoA; acetyl-CoA from myo-inositol: step 5/7. {ECO:0000255|HAMAP-
CC       Rule:MF_01668}.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC       {ECO:0000255|HAMAP-Rule:MF_01668}.
DR   EMBL; AE017262; AAT03182.1; -; Genomic_DNA.
DR   RefSeq; WP_003734601.1; NC_002973.6.
DR   SMR; Q723S9; -.
DR   EnsemblBacteria; AAT03182; AAT03182; LMOf2365_0397.
DR   KEGG; lmf:LMOf2365_0397; -.
DR   HOGENOM; HOG000235951; -.
DR   KO; K03338; -.
DR   OMA; AIVKQGP; -.
DR   BioCyc; LMON265669:G1G0V-416-MONOMER; -.
DR   UniPathway; UPA00076; UER00146.
DR   GO; GO:0047590; F:5-dehydro-2-deoxygluconokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019310; P:inositol catabolic process; ISS:JCVI.
DR   Gene3D; 2.20.150.10; -; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   HAMAP; MF_01668; IolC; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR022841; DKG_kinase_firmi.
DR   InterPro; IPR030830; Myo_inos_iolC.
DR   InterPro; IPR023314; Myo_inos_iolC-like_sf.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR029056; Ribokinase-like.
DR   Pfam; PF00294; PfkB; 1.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   TIGRFAMs; TIGR04382; myo_inos_iolC_N; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q723S9.
DR   SWISS-2DPAGE; Q723S9.
KW   ATP-binding; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    325       5-dehydro-2-deoxygluconokinase.
FT                                /FTId=PRO_0000352304.
SQ   SEQUENCE   325 AA;  35643 MW;  88E0913E50836503 CRC64;
     MNLNKHSERK FDLITVGRAC IDLNAVEYNR PMEETMTFSK YVGGSPANIA IGTAKLGLKV
     GFIGKISADQ HGRFIEKYMR DLSINTDGMV KDTEGRKVGL AFTEIKSPDE CSILMYRENV
     ADLYLTPEEI SEDYIKEARV LLISGTALAQ SPSREAVLKA VSLARKNDVA VAFELDYRPY
     TWTNTEETAV YYSLVAEQAD VIIGTRDEFD MMENQVGGKN EATKAHLFQH QAEIVVIKHG
     VEGSFAYTKA GETFQAKAYK TKVLKTFGAG DSYASAFLYG LFSGESIETA LKYGSAAASI
     VVSKHSSSDA MPTADEIKAL IAQAE
//

If you have problems or comments...

PBIL Back to PBIL home page