(data stored in ACNUC10821 zone)

SWISSPROT: LACD_LISMF

ID   LACD_LISMF              Reviewed;         338 AA.
AC   Q723B1;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 76.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE            EC=4.1.2.40 {ECO:0000255|HAMAP-Rule:MF_00734};
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE   AltName: Full=Tagatose-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
GN   Name=lacD {ECO:0000255|HAMAP-Rule:MF_00734};
GN   OrderedLocusNames=LMOf2365_0568;
OS   Listeria monocytogenes serotype 4b (strain F2365).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=265669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F2365;
RX   PubMed=15115801; DOI=10.1093/nar/gkh562;
RA   Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F.,
RA   Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D.,
RA   White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M.,
RA   Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Haft D.H.,
RA   Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A.,
RA   Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O.,
RA   Luchansky J.B., Fraser C.M.;
RT   "Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne
RT   pathogen Listeria monocytogenes reveal new insights into the core genome
RT   components of this species.";
RL   Nucleic Acids Res. 32:2386-2395(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00734};
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00734}.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00734}.
DR   EMBL; AE017262; AAT03350.1; -; Genomic_DNA.
DR   RefSeq; WP_003725443.1; NC_002973.6.
DR   SMR; Q723B1; -.
DR   EnsemblBacteria; AAT03350; AAT03350; LMOf2365_0568.
DR   KEGG; lmf:LMOf2365_0568; -.
DR   HOGENOM; HOG000241518; -.
DR   KO; K01635; -.
DR   OMA; ACDQRGG; -.
DR   BioCyc; LMON265669:G1G0V-582-MONOMER; -.
DR   UniPathway; UPA00704; UER00716.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q723B1.
DR   SWISS-2DPAGE; Q723B1.
KW   Lactose metabolism; Lyase.
FT   CHAIN           1..338
FT                   /note="Tagatose 1,6-diphosphate aldolase"
FT                   /id="PRO_0000203942"
SQ   SEQUENCE   338 AA;  37698 MW;  FC260F0DD337B53D CRC64;
     MVQITKGKFD GLQRLSNEKG VIAALAIDQR GSLKKMIQQA KGTENKKDVE DFKQLVSEEL
     TPYASAILLD LEYGTPAIKA RHEGSGLLTS YEKTGYDATT PGKLPDLIED LSALRIKENG
     GDAVKILVYY DPDEPAEINE IKYAFLERIG AECRAVDIPF FLEPITYDAT VTDSGSLEYA
     KLKPAKVKAS IKEFSKPRYG VDVLKLEVPV NFKYVEGFAE GEVAYTQDEA ARHFEECSDL
     SPLPFIYLSA GVTSEMFHKT IQFANQHNVQ YSGVLCGRAT WADGIEVYGK QGDDALREWL
     RTQGKENITS LDKLLDEGAV PWWTKYGSFE DVHVVEKQ
//

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