(data stored in SCRATCH3701 zone)

SWISSPROT: YIDC_RICTY

ID   YIDC_RICTY              Reviewed;         558 AA.
AC   Q68XS4;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   11-DEC-2019, entry version 82.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=RT0082;
OS   Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=257363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA   McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA   Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA   Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT   of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
DR   EMBL; AE017197; AAU03568.1; -; Genomic_DNA.
DR   RefSeq; WP_011190555.1; NC_006142.1.
DR   SMR; Q68XS4; -.
DR   STRING; 257363.RT0082; -.
DR   PRIDE; Q68XS4; -.
DR   EnsemblBacteria; AAU03568; AAU03568; RT0082.
DR   KEGG; rty:RT0082; -.
DR   eggNOG; ENOG4105DHW; Bacteria.
DR   eggNOG; COG0706; LUCA.
DR   HOGENOM; HOG000101821; -.
DR   KO; K03217; -.
DR   OMA; INPVAGC; -.
DR   OrthoDB; 524437at2; -.
DR   BioCyc; RTYP257363:G1G0L-85-MONOMER; -.
DR   Proteomes; UP000000604; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q68XS4.
DR   SWISS-2DPAGE; Q68XS4.
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..558
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000272372"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        332..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        474..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        520..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   558 AA;  63987 MW;  5E7852D533135342 CRC64;
     MNNNIINLIA AIVLSLSIIF GWQYFVIKPE QKKQQQRMAI YKSENLKKQK ALAEHTSNIT
     VQEAGQVQRI KIESESLTGS IALKGLRFDD LILKKYKQDL SQNSPAVRLF SPANTENAYF
     AEIGLVSNLS SVKLPNSNTV WNSDSEVLSP EKPVNLFWVN EDGIKFLVTI TVDKNYLFTI
     EQTIINNSDK ELPVQAYGLI NRKYIAVEKA VNILHQGPIG CIDENLKEYS YDDIKDQKSA
     KFALSKVDWI GIADKYWLSS LIPDKSSSYS ANFNYALKQG AERYQVDFIS PVQVIKPGKN
     LSIKSRIFAG AKKVDLLDEY EKSYDIKLFD RAIDFGWFYI ITKPVFYAMN FFYGYVGNFG
     VSILIVTVII KLLMFTLANK SYRSMKKMKN LQPEIDRIKN LYNNDKARLN QEIMALYKKS
     KVNPVAGCLP ILVQIPVFFS IYKVLYVTIE MRHAPFYGWI KDLSSPDPTT IFNLFGLLPF
     APPSFLMIGA WPILMAITMF LHQKMSPELA DPIQAQVMKF MPLIFLFMFS SFPVGLLIYW
     SWNNILSIIQ QYYINKFN
//

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