(data stored in ACNUC7421 zone)

SWISSPROT: Q4ZZS7_PSEU2

ID   Q4ZZS7_PSEU2            Unreviewed;       316 AA.
AC   Q4ZZS7;
DT   07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2005, sequence version 1.
DT   08-MAY-2019, entry version 102.
DE   RecName: Full=Homoserine kinase {ECO:0000256|HAMAP-Rule:MF_00301, ECO:0000256|SAAS:SAAS00767460};
DE            Short=HK {ECO:0000256|HAMAP-Rule:MF_00301};
DE            Short=HSK {ECO:0000256|HAMAP-Rule:MF_00301};
DE            EC=2.7.1.39 {ECO:0000256|HAMAP-Rule:MF_00301};
GN   Name=thrB {ECO:0000256|HAMAP-Rule:MF_00301};
GN   OrderedLocusNames=Psyr_0272 {ECO:0000313|EMBL:AAY35345.1};
OS   Pseudomonas syringae pv. syringae (strain B728a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=205918 {ECO:0000313|EMBL:AAY35345.1, ECO:0000313|Proteomes:UP000000426};
RN   [1] {ECO:0000313|EMBL:AAY35345.1, ECO:0000313|Proteomes:UP000000426}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B728a {ECO:0000313|EMBL:AAY35345.1,
RC   ECO:0000313|Proteomes:UP000000426};
RX   PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA   Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA   Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA   Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA   Kyrpides N.C., Ivanova N., Lindow S.E.;
RT   "Comparison of the complete genome sequences of Pseudomonas syringae
RT   pv. syringae B728a and pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine;
CC         Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216;
CC         EC=2.7.1.39; Evidence={ECO:0000256|HAMAP-Rule:MF_00301,
CC         ECO:0000256|SAAS:SAAS01124410};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5. {ECO:0000256|HAMAP-
CC       Rule:MF_00301, ECO:0000256|SAAS:SAAS00767466}.
CC   -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00301, ECO:0000256|SAAS:SAAS00767468}.
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DR   EMBL; CP000075; AAY35345.1; -; Genomic_DNA.
DR   RefSeq; WP_011266290.1; NC_007005.1.
DR   RefSeq; YP_233383.1; NC_007005.1.
DR   STRING; 205918.Psyr_0272; -.
DR   EnsemblBacteria; AAY35345; AAY35345; Psyr_0272.
DR   GeneID; 3365748; -.
DR   KEGG; psb:Psyr_0272; -.
DR   PATRIC; fig|205918.7.peg.272; -.
DR   eggNOG; ENOG4105CUV; Bacteria.
DR   eggNOG; COG2334; LUCA.
DR   HOGENOM; HOG000004810; -.
DR   KO; K02204; -.
DR   OMA; AGALRFW; -.
DR   BioCyc; PSYR205918:G1G4J-273-MONOMER; -.
DR   UniPathway; UPA00050; UER00064.
DR   Proteomes; UP000000426; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd05153; HomoserineK_II; 1.
DR   HAMAP; MF_00301; Homoser_kinase_2; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR005280; Homoserine_kinase_II.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   TIGRFAMs; TIGR00938; thrB_alt; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4ZZS7.
DR   SWISS-2DPAGE; Q4ZZS7.
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767464};
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767472};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000426};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767471, ECO:0000313|EMBL:AAY35345.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767462};
KW   Threonine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767467};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767469, ECO:0000313|EMBL:AAY35345.1}.
FT   DOMAIN       28    255       APH. {ECO:0000259|Pfam:PF01636}.
SQ   SEQUENCE   316 AA;  35430 MW;  AFDC4BAF3181E30A CRC64;
     MSVFTPLARP ELETFLAPYG LGRLLDYQGI AAGSENTNYF ISLEQGEFVL TLVERGPVQE
     MPFFIELLDV LHEADLPVPY ALRTTDGQAL RELADKPALL QPRLPGKHIS EPNTQHCVQI
     GELLANLHLA TRGQIVERKT DRGLDWMLSE GRNFLSHLGE TQRALLEKSL QEIEACKPQI
     MALPRANLHA DLFRDNVLFE GTHLTGLIDF YNACSGPMLY DLAITLNDWC SRENGQLDAV
     RARALLGAYA GLRPFTAAES KLWATMLRIA CVRFWLSRLI AAETFAGQDV LIHDPAEFER
     RLAERQEAHI ALPFAL
//

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