(data stored in ACNUC7421 zone)

SWISSPROT: Q4ZZQ7_PSEU2

ID   Q4ZZQ7_PSEU2            Unreviewed;       336 AA.
AC   Q4ZZQ7;
DT   07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2005, sequence version 1.
DT   08-MAY-2019, entry version 81.
DE   RecName: Full=Delta-aminolevulinic acid dehydratase {ECO:0000256|RuleBase:RU000515};
DE            EC=4.2.1.24 {ECO:0000256|RuleBase:RU000515};
GN   OrderedLocusNames=Psyr_0292 {ECO:0000313|EMBL:AAY35365.1};
OS   Pseudomonas syringae pv. syringae (strain B728a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=205918 {ECO:0000313|EMBL:AAY35365.1, ECO:0000313|Proteomes:UP000000426};
RN   [1] {ECO:0000313|EMBL:AAY35365.1, ECO:0000313|Proteomes:UP000000426}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B728a {ECO:0000313|EMBL:AAY35365.1,
RC   ECO:0000313|Proteomes:UP000000426};
RX   PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA   Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA   Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA   Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA   Kyrpides N.C., Ivanova N., Lindow S.E.;
RT   "Comparison of the complete genome sequences of Pseudomonas syringae
RT   pv. syringae B728a and pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen;
CC         Xref=Rhea:RHEA:24064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58126, ChEBI:CHEBI:356416; EC=4.2.1.24;
CC         Evidence={ECO:0000256|RuleBase:RU000515};
CC   -!- SUBUNIT: Homooctamer. {ECO:0000256|RuleBase:RU000515}.
CC   -!- SIMILARITY: Belongs to the ALAD family.
CC       {ECO:0000256|RuleBase:RU004161}.
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DR   EMBL; CP000075; AAY35365.1; -; Genomic_DNA.
DR   RefSeq; WP_003403849.1; NC_007005.1.
DR   RefSeq; YP_233403.1; NC_007005.1.
DR   STRING; 205918.Psyr_0292; -.
DR   EnsemblBacteria; AAY35365; AAY35365; Psyr_0292.
DR   GeneID; 3365768; -.
DR   KEGG; psb:Psyr_0292; -.
DR   PATRIC; fig|205918.7.peg.294; -.
DR   eggNOG; ENOG4105D52; Bacteria.
DR   eggNOG; COG0113; LUCA.
DR   HOGENOM; HOG000020323; -.
DR   KO; K01698; -.
DR   OMA; YQMDYAN; -.
DR   BioCyc; PSYR205918:G1G4J-293-MONOMER; -.
DR   Proteomes; UP000000426; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004655; F:porphobilinogen synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR001731; ALAD.
DR   InterPro; IPR030656; ALAD_AS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   PANTHER; PTHR11458; PTHR11458; 1.
DR   Pfam; PF00490; ALAD; 1.
DR   PIRSF; PIRSF001415; Porphbilin_synth; 1.
DR   PRINTS; PR00144; DALDHYDRTASE.
DR   SMART; SM01004; ALAD; 1.
DR   PROSITE; PS00169; D_ALA_DEHYDRATASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4ZZQ7.
DR   SWISS-2DPAGE; Q4ZZQ7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000426};
KW   Lyase {ECO:0000256|RuleBase:RU000515, ECO:0000313|EMBL:AAY35365.1};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR001415-5};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001415-5};
KW   Porphyrin biosynthesis {ECO:0000256|RuleBase:RU000515}.
FT   ACT_SITE    205    205       Schiff-base intermediate with substrate.
FT                                {ECO:0000256|PIRSR:PIRSR001415-1}.
FT   ACT_SITE    260    260       Schiff-base intermediate with substrate.
FT                                {ECO:0000256|PIRSR:PIRSR001415-1}.
FT   METAL       245    245       Magnesium. {ECO:0000256|PIRSR:
FT                                PIRSR001415-5}.
SQ   SEQUENCE   336 AA;  36935 MW;  C6DA8C42556AA4B4 CRC64;
     MSFTPANRLF PLTRLRRNRR DDFSRRLVRE NVVTVDDLIL PVFVLDGENR RESIASMPGV
     ERLSVDLLLK EAEHWVALGI PALALFPVTP PEKKSLDGAE AWNPDGIAQR ATRALRDRFP
     ELGVITDVAL DPFTTHGQDG ILDEEGYVQN DITVDALVKQ ALSHADAGAQ VIAPSDMMDG
     RIQAIRESLE LAGHVNVRIM AYSAKYASAY YGPFRDAVGS SLNLGKANKA SYQMDPANSN
     EALHEVAADL AEGADMVMVK PGMPYLDILY RVKDEFKVPT FVYQVSGEYA MHMAAIQNGW
     LSEGVILESL TAFKRAGADG ILTYFAVRAA QLLKGQ
//

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